HitPredict

Interactor 1: GID4 (Q8IVV7)
Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog)
Gene: GID4

Interactor 2: RMD5A (Q9H871)
E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A)
Gene: RMND5A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	27173435, 31285494, 26186194, 28514442, 29911972, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0034657 - GID complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 300 Hs			1 391
+	Hs
		1185114 GID4_HUMAN (1-300): 3.35e-161: 452: 100.00		MAEA_HUMAN (25-390): 1.22e-111: 334: 20.05
+	Hs
		1218047 GID4_HUMAN (1-300): 3.35e-161: 452: 100.00		GID8_HUMAN (114-280): 5.61e-39: 141: 17.54
+	Hs
		1218034 GID4_HUMAN (1-300): 3.35e-161: 452: 100.00		RANB9_HUMAN (87-214): 3.61e-11: 66.7: 16.41
+	Sc
		747300 GID4_YEAST (102-299): 3.45e-63: 205: 27.80		RMD5_YEAST (10-391): 2.85e-90: 280: 24.22
+	Sc
		747273 GID4_YEAST (102-299): 3.45e-63: 205: 27.80		FYV10_YEAST (23-390): 1.01e-39: 149: 14.09