HitPredict

Interactor 1: SRC8 (Q60598)
Src substrate cortactin
Gene: Cttn

Interactor 2: ARP3 (Q99JY9)
Actin-related protein 3 (Actin-like protein 3)
Gene: Actr3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	11018051
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001726 - ruffle GO:0005737 - cytoplasm GO:0005884 - actin filament GO:0030027 - lamellipodium GO:0030838 - positive regulation of actin filament polymerization and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 546 Mm			1 418
+	Hs
		958101 SRC8_HUMAN (1-546): 5.76e-164: 479: 92.18		ARP3_HUMAN (1-418): 0: 587: 99.76
+	Hs
		952816 SRC8_HUMAN (1-546): 5.76e-164: 479: 92.18		ACTB_HUMAN (1-414): 0: 534: 35.90
+	Hs
		993176 SRC8_HUMAN (1-546): 5.76e-164: 479: 92.18		ACTG_HUMAN (1-414): 0: 533: 35.66
+	Hs
		995590 SRC8_HUMAN (1-546): 5.76e-164: 479: 92.18		ACTC_HUMAN (3-414): 0: 522: 35.84
+	Hs
		571665 HCLS1_HUMAN (1-546): 6.71e-117: 356: 38.39		ARP3_HUMAN (1-418): 0: 587: 99.76
+	Dm
		1014448 Q9VDF4_DROME (1-545): 4.57e-117: 359: 39.96		ACT6_DROME (3-414): 0: 525: 35.11
+	Hs
		958103 LASP1_HUMAN (302-545): 3e-38: 143: 20.88		ARP3_HUMAN (1-418): 0: 587: 99.76
+	Hs
		993383 PACN2_HUMAN (169-546): 2.08e-40: 154: 14.17		ACTG_HUMAN (1-414): 0: 533: 35.66
+	Hs
		952809 SPTN1_HUMAN (141-545): 3.52e-35: 143: 14.03		ACTB_HUMAN (1-414): 0: 534: 35.90
+	Hs
		952824 LASP1_HUMAN (302-545): 3e-38: 143: 20.88		ACTB_HUMAN (1-414): 0: 534: 35.90
+	Hs
		993169 SPTN1_HUMAN (141-545): 3.52e-35: 143: 14.03		ACTG_HUMAN (1-414): 0: 533: 35.66
+	Dm
		534413 SPTCA_DROME (140-545): 1.32e-34: 141: 12.93		ACT1_DROME (3-414): 0: 529: 35.59
+	Dm
		386970 SPTCA_DROME (140-545): 1.32e-34: 141: 12.93		ACT2_DROME (3-414): 0: 527: 35.35
+	Dm
		534342 SPTCA_DROME (140-545): 1.32e-34: 141: 12.93		ACT5_DROME (3-414): 0: 527: 35.59
+	Dm
		561565 SPTCA_DROME (140-545): 1.32e-34: 141: 12.93		ACT3_DROME (3-414): 0: 525: 35.59
+	Dm
		561567 SPTCA_DROME (140-545): 1.32e-34: 141: 12.93		ACT6_DROME (3-414): 0: 525: 35.11
+	Mm
		977879 LASP1_MOUSE (302-545): 1.2e-38: 144: 21.69		ACTA_MOUSE (3-414): 0: 521: 35.84
+	Hs
		995581 SPTN1_HUMAN (141-545): 3.52e-35: 143: 14.03		ACTC_HUMAN (3-414): 0: 522: 35.84
+	Hs
		996450 SPTN1_HUMAN (141-545): 3.52e-35: 143: 14.03		ACTS_HUMAN (3-414): 0: 522: 35.84
+	Dm
		387023 SPTCA_DROME (140-545): 1.32e-34: 141: 12.93		ACT4_DROME (3-414): 0: 520: 35.59