HitPredict

Interactor 1: YAF2 (Q8IY57)
YY1-associated factor 2
Gene: YAF2

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	28514442, 27705803, 24981860, 33961781, 22325352
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 180 Hs			1 350
+	Hs
		718000 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		718409 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		1108516 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Mm
		1208122 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		PCGF6_MOUSE (41-350): 5.4e-85: 262: 92.90
+	Hs
		1222217 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		1197569 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Mm
		620789 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		PCGF2_MOUSE (117-350): 1.96e-62: 204: 33.88
+	Dm
		1374687 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		Q9VV77_DROME (120-344): 1.81e-62: 200: 37.45
+	Dm
		728817 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		PSC_DROME (42-349): 1.28e-53: 192: 28.08
+	Mm
		1208119 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		PCGF1_MOUSE (119-347): 7.81e-60: 194: 35.35
+	Mm
		1307837 YAF2_MOUSE (1-180): 3.8e-76: 227: 91.67		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		1019331 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		TRI26_HUMAN (121-315): 1.51e-31: 126: 19.90
+	Hs
		1222214 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		987989 YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Dm
		627173 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		SUZ2_DROME (102-344): 1.15e-39: 151: 20.72
+	Hs
		585013 RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78		RO52_HUMAN (121-311): 4.15e-35: 135: 17.79
+	Mm
		1208123 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		282696 RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78		RNF8_HUMAN (74-217): 4.44e-28: 115: 24.16
+	Dm
		1361718 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		RING1_DROME (108-243): 1.25e-26: 111: 22.63
+	Mm
		193411 RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78		RING1_MOUSE (109-211): 8.51e-26: 108: 25.96