HitPredict

Interactor 1: FCSD1 (Q86WN1)
F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2)
Gene: FCHSD1

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	19041431, 22558309
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FCH~SH3_9, SH3_2~SH3_9, SH3_9~SH3_9
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 690 Hs			1 1697
+	Hs
		319248 FCSD2_HUMAN (1-685): 1.31e-83: 281: 35.82		ITSN2_HUMAN (1-1697): 0: 934: 100.00
+	Hs
		319213 FCSD2_HUMAN (1-685): 1.31e-83: 281: 35.82		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		1453434 ITSN2_HUMAN (4-628): 1.89e-21: 102: 12.62		ITSN2_HUMAN (1-1697): 0: 934: 100.00
+	Hs
		1154159 FNBP1_HUMAN (14-614): 1.32e-49: 185: 13.31		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		1070497 FCHO2_HUMAN (11-617): 1.13e-39: 158: 11.61		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		1154182 ITSN2_HUMAN (4-628): 1.89e-21: 102: 12.62		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		1154087 ITSN1_HUMAN (374-631): 8.49e-21: 100: 16.41		ITSN1_HUMAN (2-1693): 0: 828: 56.00
+	Hs
		1154138 ITSN1_HUMAN (374-631): 8.49e-21: 100: 16.41		PREX1_HUMAN (1167-1594): 4.19e-71: 266: 19.06
+	Hs
		584461 VAV_HUMAN (1-606): 4.78e-61: 221: 14.20		VAV_HUMAN (255-1041): 6.16e-24: 111: 12.88
+	Hs
		1070518 FCHO2_HUMAN (11-617): 1.13e-39: 158: 11.61		EP15R_HUMAN (11-510): 1.51e-36: 152: 16.77
+	Hs
		839750 FCHO2_HUMAN (11-617): 1.13e-39: 158: 11.61		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Hs
		64409 A6H8W8_HUMAN (40-628): 4.18e-22: 104: 13.64		EP15R_HUMAN (11-510): 1.51e-36: 152: 16.77
+	Hs
		1453438 ITSN2_HUMAN (4-628): 1.89e-21: 102: 12.62		EP15R_HUMAN (11-510): 1.51e-36: 152: 16.77
+	Hs
		1154186 ITSN1_HUMAN (374-631): 8.49e-21: 100: 16.41		EP15R_HUMAN (11-510): 1.51e-36: 152: 16.77
+	Hs
		64403 A6H8W8_HUMAN (40-628): 4.18e-22: 104: 13.64		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Hs
		839838 ITSN2_HUMAN (4-628): 1.89e-21: 102: 12.62		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Hs
		839768 ITSN1_HUMAN (374-631): 8.49e-21: 100: 16.41		EPS15_HUMAN (7-420): 8.38e-32: 137: 14.73
+	Cl
		47464 F1PHV6_CANLF (368-631): 3.94e-21: 101: 16.05		A0A8I3PJA6_CANLF (197-676): 6.62e-30: 131: 18.31
+	Hs
		299586 ITSN2_HUMAN (4-628): 1.89e-21: 102: 12.62		TRIO_HUMAN (178-881): 2.4e-11: 71.4: 8.54