Protein: NPHP1
Nephrocystin-1 (Juvenile nephronophthisis 1 protein)

Gene: NPHP1
Organism: Homo sapiens
Interactions: 101
UniProt ID: O15259

Gene Ontology (top 5):
GO:0005198 - structural molecule activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184280

BCAR1
Breast cancer anti-estrogen resistance protein 1

3

3

Small-scale

0.871

High

184301

FTM
Protein fantom

3

2

High-throughput

0.861

High

184286

ACK1
Activated CDC42 kinase 1

2

1

Small-scale

0.807

High

184293

FAK2
Protein-tyrosine kinase 2-beta

2

1

Small-scale

0.806

High

184253

NPHP4
Nephrocystin-4

6

4

Small-scale

0.735

High

184326

UBQL4
Ubiquilin-4

1

2

High-throughput

0.698

High

184311

RPGR
X-linked retinitis pigmentosa GTPase regulator

3

1

Small-scale

0.667

High

184309

AHI1
Jouberin

1

1

Small-scale

0.665

High

184290

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

2

2

Small-scale

0.646

High

184314

DNJC7
DnaJ homolog subfamily C member 7

2

1

High-throughput

0.628

High

184249

NPHP1
Nephrocystin-1

1

1

Small-scale

0.618

High

184299

SH319
SH3 domain-containing protein 19

1

1

High-throughput

0.618

High

184303

DNMBP
Dynamin-binding protein

1

1

High-throughput

0.618

High

184340

INVS
Inversin

1

4

Small-scale

0.618

High

184335

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

0

Small-scale

0.614

High

184267

KCNA5
Potassium voltage-gated channel subfamily A member 5

2

0

High-throughput

0.602

High

67585

RHG32
Rho GTPase-activating protein 32

1

0

Small-scale

0.589

High

184269

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.586

High

184276

DYN2
Dynamin-2

1

0

High-throughput

0.586

High

184324

TENS1
Tensin-1

1

0

Small-scale

0.586

High

184345

SNX9
Sorting nexin-9

1

0

High-throughput

0.586

High

184313

TM237
Transmembrane protein 237

2

0

High-throughput

0.585

High

184281

PKD1
Polycystin-1

1

0

Small-scale

0.578

High

184266

FLNA
Filamin-A

1

2

Small-scale

0.552

High

184265

FILA
Filaggrin

1

1

High-throughput

0.536

High

184279

TTC3
E3 ubiquitin-protein ligase TTC3

1

2

High-throughput

0.536

High

184302

ZN746
Zinc finger protein 746

1

1

High-throughput

0.536

High

184318

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.493

High

184331

ZN282
Zinc finger protein 282

1

1

High-throughput

0.489

High

184254

FLNB
Filamin-B

1

2

Small-scale

0.481

High

184342

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

137865

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

184257

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.479

High

184259

TBB5
Tubulin beta chain

1

2

Small-scale

0.479

High

184277

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

1

High-throughput

0.479

High

184295

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

184306

NPHP3
Nephrocystin-3

1

1

Small-scale

0.479

High

184319

UN45A
Protein unc-45 homolog A

1

2

High-throughput

0.479

High

184320

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.479

High

184329

SPAT7
Spermatogenesis-associated protein 7

1

1

Small-scale

0.479

High

184338

CE164
Centrosomal protein of 164 kDa

1

2

Small-scale

0.479

High

184339

RUVB1
RuvB-like 1

1

1

Small-scale

0.479

High

184344

HYOU1
Hypoxia up-regulated protein 1

1

2

High-throughput

0.479

High

184251

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

184256

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.458

High

184258

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.458

High

184260

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

High-throughput

0.458

High

184261

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

184262

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.458

High

184263

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

0

High-throughput

0.458

High

184264

RAB6A
Ras-related protein Rab-6A

1

0

High-throughput

0.458

High

184268

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

184271

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.458

High

184272

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

184273

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

184274

PRC2A
Protein PRRC2A

1

0

High-throughput

0.458

High

184278

COPA
Coatomer subunit alpha

1

0

High-throughput

0.458

High

184282

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

184283

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.458

High

184284

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

0

High-throughput

0.458

High

184287

FCHO2
F-BAR domain only protein 2

1

0

High-throughput

0.458

High

184288

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.458

High

184289

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

184291

TTL12
Tubulin--tyrosine ligase-like protein 12

1

0

High-throughput

0.458

High

184292

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

184294

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.458

High

184296

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

184298

AGK
Acylglycerol kinase, mitochondrial

1

0

High-throughput

0.458

High

184300

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.458

High

184304

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

0

High-throughput

0.458

High

184307

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.458

High

184308

PHAR4
Phosphatase and actin regulator 4

1

0

High-throughput

0.458

High

184310

TM256
Transmembrane protein 256

1

0

High-throughput

0.458

High

184321

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.458

High

184322

WDR41
WD repeat-containing protein 41

1

0

High-throughput

0.458

High

184323

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

184325

TM9S3
Transmembrane 9 superfamily member 3

1

0

High-throughput

0.458

High

184327

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.458

High

184328

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

184330

UXT
Protein UXT

1

0

High-throughput

0.458

High

184332

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

184333

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

0

High-throughput

0.458

High

184334

XPO7
Exportin-7

1

0

High-throughput

0.458

High

184336

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

184337

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.458

High

184341

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.458

High

184346

S23IP
SEC23-interacting protein

1

0

High-throughput

0.458

High

184250

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

2

Small-scale

0.457

High

184317

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

2

Small-scale

0.457

High

184270

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

1

High-throughput

0.437

High

184305

CE128
Centrosomal protein of 128 kDa

1

2

High-throughput

0.437

High

184285

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

Small-scale

0.391

High

184297

TIGD5
Tigger transposable element-derived protein 5

1

0

High-throughput

0.279

Low

184252

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

184255

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.249

Low

184275

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.249

Low

184312

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

184315

GPTC1
G patch domain-containing protein 1

1

0

High-throughput

0.249

Low

184316

WDR83
WD repeat domain-containing protein 83

1

0

High-throughput

0.249

Low

184343

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025