HitPredict

Interactor 1: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Interactor 2: ES8L1 (Q8TE68)
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)
Gene: EPS8L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	14565974, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0045296 - cadherin binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 723
+	Hs
		1020381 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		EPS8_HUMAN (3-716): 0: 754: 34.96
+	Mm
		995948 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		EPS8_MOUSE (3-716): 0: 753: 35.60
+	Hs
		1224645 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		ES8L2_HUMAN (6-709): 0: 722: 39.37
+	Mm
		913884 ABI2_MOUSE (1-508): 4.85e-88: 279: 61.18		EPS8_MOUSE (3-716): 0: 753: 35.60
+	Hs
		1224619 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		ES8L3_HUMAN (11-614): 7.35e-173: 509: 29.71
+	Hs
		411788 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		LCK_HUMAN (417-701): 3.51e-67: 232: 15.36
+	Hs
		442853 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		HCK_HUMAN (403-704): 4.07e-60: 213: 16.86
+	Hs
		523060 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		SRC_HUMAN (423-704): 1.43e-57: 206: 13.60
+	Hs
		433413 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		YES_HUMAN (423-704): 9.94e-57: 204: 12.58
+	Hs
		412258 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		FYN_HUMAN (430-704): 9.77e-56: 201: 13.07
+	Hs
		433885 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		LYN_HUMAN (451-704): 2.54e-55: 199: 15.89
+	Hs
		454841 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		FGR_HUMAN (437-704): 1.28e-54: 198: 12.07
+	Hs
		996567 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		ITK_HUMAN (361-718): 2.59e-52: 193: 13.46
+	Hs
		209108 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		NCK2_HUMAN (478-605): 1.59e-36: 143: 23.70
+	Hs
		557737 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		NCK1_HUMAN (478-605): 5.2e-32: 130: 22.96
+	Mm
		223016 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		NCK2_MOUSE (380-601): 3.72e-10: 64.5: 14.46
+	Hs
		209180 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		NCK2_HUMAN (478-605): 1.59e-36: 143: 23.70
+	Hs
		3136 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		A0A0S2Z4D7_HUMAN (478-605): 1.92e-34: 131: 22.96
+	Hs
		557806 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		NCK1_HUMAN (478-605): 5.2e-32: 130: 22.96
+	Hs
		3146 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		A0A0S2Z4E4_HUMAN (478-605): 5.83e-33: 129: 22.96