HitPredict

Interactor 1: K1C40 (Q6A162)
Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)
Gene: KRT40

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 431 Hs			1 594
+	Hs
		1230336 K1C39_HUMAN (2-430): 3.24e-153: 444: 50.11		SHC3_HUMAN (1-594): 0: 587: 100.00
+	Hs
		300448 KRT34_HUMAN (29-430): 8.4e-153: 440: 62.53		SHC3_HUMAN (1-594): 0: 587: 100.00
+	Hs
		385057 K1C14_HUMAN (87-400): 4.33e-146: 425: 53.82		SHC1_HUMAN (3-593): 6.56e-176: 512: 47.06
+	Hs
		1127668 KT33B_HUMAN (23-429): 1.32e-111: 335: 58.48		SHC3_HUMAN (1-594): 0: 587: 100.00
+	Hs
		711316 K1C17_HUMAN (82-401): 2.07e-100: 307: 52.81		SHC1_HUMAN (3-593): 6.56e-176: 512: 47.06
+	Hs
		476272 K1C16_HUMAN (85-412): 2.57e-96: 298: 51.52		SHC1_HUMAN (3-593): 6.56e-176: 512: 47.06
+	Hs
		1193603 K1C39_HUMAN (2-430): 3.24e-153: 444: 50.11		Q49AR9_HUMAN (11-487): 6.24e-59: 208: 13.32
+	Hs
		300371 KRT34_HUMAN (29-430): 8.4e-153: 440: 62.53		Q49AR9_HUMAN (11-487): 6.24e-59: 208: 13.32
+	Hs
		1230337 K1C39_HUMAN (2-430): 3.24e-153: 444: 50.11		ANS1A_HUMAN (11-377): 8.7e-54: 199: 15.78
+	Hs
		300450 KRT34_HUMAN (29-430): 8.4e-153: 440: 62.53		ANS1A_HUMAN (11-377): 8.7e-54: 199: 15.78
+	Hs
		300284 KRT34_HUMAN (29-430): 8.4e-153: 440: 62.53		HCK_HUMAN (360-594): 1.09e-45: 170: 15.14
+	Mm
		431366 K2C5_MOUSE (60-411): 1.57e-146: 430: 26.33		SRC_MOUSE (361-594): 3.66e-49: 180: 17.46
+	Hs
		300333 KRT34_HUMAN (29-430): 8.4e-153: 440: 62.53		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		385083 K1C14_HUMAN (87-400): 4.33e-146: 425: 53.82		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Mm
		431354 K1C14_MOUSE (88-400): 3.04e-95: 296: 52.72		SRC_MOUSE (361-594): 3.66e-49: 180: 17.46
+	Hs
		987640 KT33B_HUMAN (23-429): 1.32e-111: 335: 58.48		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		475554 K1C19_HUMAN (82-397): 4.57e-103: 313: 51.90		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		987559 K1C17_HUMAN (82-401): 2.07e-100: 307: 52.81		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		476293 K1C16_HUMAN (85-412): 2.57e-96: 298: 51.52		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		618017 K1C15_HUMAN (88-401): 4.67e-95: 295: 52.38		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08