HitPredict

Interactor 1: K1C16 (P08779)
Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)
Gene: KRT16

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 473 Hs			1 217
+	Hs
		987559 K1C17_HUMAN (110-445): 1.95e-170: 488: 79.46		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		618017 K1C15_HUMAN (116-429): 2.98e-155: 450: 76.19		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		385083 K1C14_HUMAN (1-448): 4.71e-152: 442: 83.48		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		475554 K1C19_HUMAN (106-434): 2.35e-146: 425: 69.61		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		300264 KT33A_HUMAN (63-443): 2.3e-139: 407: 51.44		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		987640 KT33B_HUMAN (67-443): 4.68e-138: 404: 51.19		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		566126 K1C10_HUMAN (112-422): 7.6e-130: 390: 67.52		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		300333 KRT34_HUMAN (110-437): 1.12e-117: 352: 56.16		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		987642 KRT81_HUMAN (8-428): 1.92e-99: 309: 26.07		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		227210 KRT86_HUMAN (8-428): 1.49e-98: 306: 25.83		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		987535 KRT83_HUMAN (16-428): 2.35e-98: 306: 26.91		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		987749 K2C73_HUMAN (3-431): 9.68e-96: 300: 24.83		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		987536 KRT85_HUMAN (10-428): 2.9e-93: 293: 28.44		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Mm
		431354 K1C14_MOUSE (1-467): 1.36e-146: 429: 75.00		SRC_MOUSE (161-215): 3.32e-10: 60.8: 31.58
+	Mm
		431382 K1C16_MOUSE (1-461): 9.38e-144: 421: 80.04		SRC_MOUSE (161-215): 3.32e-10: 60.8: 31.58
+	Hs
		292806 K1C13_HUMAN (105-441): 6.51e-139: 408: 69.82		GRAP2_HUMAN (3-55): 1.97e-10: 61.3: 39.62
+	Hs
		557056 K1C10_HUMAN (112-422): 7.6e-130: 390: 67.52		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		362297 K1H1_HUMAN (67-452): 6.38e-113: 340: 50.78		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		300284 KRT34_HUMAN (110-437): 1.12e-117: 352: 56.16		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90
+	Hs
		473424 K1H1_HUMAN (67-452): 6.38e-113: 340: 50.78		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90