HitPredict

Interactor 1: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Interactor 2: DCLK1 (Q9JLM8)
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Gene: DCLK1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30562941, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0014069 - postsynaptic density GO:0098978 - glutamatergic synapse GO:0150052 - regulation of postsynapse assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 817 Mm			1 756
+	Hs
		176869 NEB2_HUMAN (1-817): 4.8e-111: 359: 95.84		DCLK1_HUMAN (1-756): 0: 840: 96.43
+	Hs
		176895 NEB1_HUMAN (1-817): 6.85e-101: 338: 46.73		DCLK1_HUMAN (1-756): 0: 840: 96.43
+	Hs
		1327403 NEB2_HUMAN (1-817): 4.8e-111: 359: 95.84		DCLK2_HUMAN (1-746): 0: 756: 63.04
+	Hs
		1327406 NEB1_HUMAN (1-817): 6.85e-101: 338: 46.73		DCLK2_HUMAN (1-746): 0: 756: 63.04
+	Hs
		176809 AFAD_HUMAN (397-798): 1.75e-38: 157: 18.69		DCLK1_HUMAN (1-756): 0: 840: 96.43
+	Mm
		313044 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		DCX_MOUSE (6-346): 2.36e-134: 403: 72.21
+	Mm
		1244501 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		KCC2D_MOUSE (401-741): 6.09e-131: 399: 34.49
+	Hs
		221285 NEB2_HUMAN (1-817): 4.8e-111: 359: 95.84		DCX_HUMAN (6-344): 5.4e-134: 402: 72.62
+	Rn
		204571 NEB2_RAT (1-817): 3.55e-116: 373: 98.90		KCC2D_RAT (402-744): 8.75e-126: 387: 34.29
+	Mm
		548958 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		KCC2A_MOUSE (402-727): 2.14e-125: 384: 37.46
+	Hs
		1146461 NEB2_HUMAN (1-817): 4.8e-111: 359: 95.84		KS6A2_HUMAN (397-734): 6.96e-114: 363: 25.21
+	Hs
		1148405 NEB1_HUMAN (1-817): 6.85e-101: 338: 46.73		KS6A1_HUMAN (355-736): 1.14e-111: 357: 21.66
+	Rn
		204569 NEB2_RAT (1-817): 3.55e-116: 373: 98.90		KCC2G_RAT (403-663): 7.56e-66: 229: 44.15
+	Rn
		204568 NEB2_RAT (1-817): 3.55e-116: 373: 98.90		KCC2A_RAT (403-664): 8.44e-66: 228: 42.86
+	Mm
		1247164 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		KCC2G_MOUSE (403-663): 2.13e-65: 228: 44.15
+	Rn
		204567 NEB2_RAT (1-817): 3.55e-116: 373: 98.90		KCC2B_RAT (403-663): 1.45e-63: 223: 44.15
+	Mm
		704222 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		KCC2B_MOUSE (403-663): 1.39e-63: 223: 44.15
+	Hs
		1399284 LRRC7_HUMAN (15-586): 7.55e-41: 164: 12.93		KCC2A_HUMAN (402-741): 1.88e-125: 384: 37.10
+	Hs
		1368733 DLG3_HUMAN (267-734): 3.47e-40: 161: 14.72		KCC2A_HUMAN (402-741): 1.88e-125: 384: 37.10
+	Hs
		1148365 PAR3L_HUMAN (159-758): 2.61e-42: 168: 15.56		KS6A1_HUMAN (355-736): 1.14e-111: 357: 21.66