HitPredict

Interactor 1: CHD5 (Q8TDI0)
Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)
Gene: CHD5

Interactor 2: MB3L1 (Q8WWY6)
Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1)
Gene: MBD3L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1954 Hs			1 194
+	Hs
		328615 CHD5_HUMAN (1-1954): 0: 1751: 100.00		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		1255049 CHD5_HUMAN (1-1954): 0: 1751: 100.00		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		1246251 CHD5_HUMAN (1-1954): 0: 1751: 100.00		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Hs
		328540 CHD3_HUMAN (28-1952): 0: 1551: 66.72		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		1018609 CHD3_HUMAN (28-1952): 0: 1551: 66.72		MB3L1_HUMAN (1-194): 1.26e-98: 285: 100.00
+	Hs
		1018729 CHD3_HUMAN (28-1952): 0: 1551: 66.72		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		328558 CHD4_HUMAN (51-1916): 0: 1500: 70.29		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		1059762 CHD4_HUMAN (51-1916): 0: 1500: 70.29		MB3L1_HUMAN (1-194): 1.26e-98: 285: 100.00
+	Mm
		1125399 Q5DTP7_MOUSE (10-1907): 0: 1484: 68.69		MBD3_MOUSE (1-193): 1.26e-101: 296: 43.52
+	Mm
		1161084 CHD4_MOUSE (10-1907): 0: 1478: 68.86		MBD3_MOUSE (1-193): 1.26e-101: 296: 43.52
+	Hs
		1059915 CHD4_HUMAN (51-1916): 0: 1500: 70.29		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		1018596 CHD3_HUMAN (28-1952): 0: 1551: 66.72		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Hs
		1059746 CHD4_HUMAN (51-1916): 0: 1500: 70.29		MB3L2_HUMAN (26-187): 5.81e-61: 190: 45.73
+	Dm
		332827 CHDM_DROME (15-1942): 0: 1349: 49.51		Q9V424_DROME (19-172): 3.98e-61: 191: 28.66
+	Dm
		332848 CHDM_DROME (15-1942): 0: 1349: 49.51		Q9VHB7_DROME (19-172): 3.67e-59: 190: 28.66
+	Hs
		229269 SMCA5_HUMAN (575-1643): 0: 743: 26.22		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		328499 SMCA1_HUMAN (584-1628): 0: 724: 25.42		MBD3_HUMAN (1-193): 3.4e-102: 297: 44.56
+	Hs
		229512 SMCA5_HUMAN (575-1643): 0: 743: 26.22		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76
+	Hs
		658746 SMCA1_HUMAN (584-1628): 0: 724: 25.42		MBD2_HUMAN (1-182): 5.61e-85: 258: 41.76