HitPredict

Interactor 1: DI3L1 (Q8TF46)
DIS3-like exonuclease 1 (EC 3.1.13.1)
Gene: DIS3L

Interactor 2: EXOS4 (Q9NPD3)
Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)
Gene: EXOSC4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	26496610, 24981860, 33961781, 20531386
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, OB_Dis3~RNase_PH_C, RNB~RNase_PH
Common GO terms	GO:0000175 - 3'-5'-RNA exonuclease activity GO:0000177 - cytoplasmic exosome (RNase complex) GO:0005829 - cytosol GO:0006396 - RNA processing GO:0006401 - RNA catabolic process and 1 others more... GO:0016075 - rRNA catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1054 Hs			1 245
+	Hs
		1257149 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS8_HUMAN (1-234): 4.22e-62: 197: 18.73
+	Hs
		1257154 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS5_HUMAN (2-239): 3.39e-52: 170: 26.25
+	Hs
		1063744 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS7_HUMAN (3-244): 6.35e-51: 169: 16.01
+	Hs
		1130037 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS6_HUMAN (6-232): 3.11e-47: 159: 29.05
+	Hs
		1342631 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS4_HUMAN (1-245): 1.14e-89: 266: 100.00
+	Hs
		1284999 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS8_HUMAN (1-234): 4.22e-62: 197: 18.73
+	Hs
		1343596 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS5_HUMAN (2-239): 3.39e-52: 170: 26.25
+	Hs
		1063785 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS7_HUMAN (3-244): 6.35e-51: 169: 16.01
+	At
		96521 F4INI6_ARATH (1-972): 0: 934: 31.24		RRP41_ARATH (4-238): 4.5e-83: 249: 48.51
+	Dm
		1362696 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VK19_DROME (4-236): 1.16e-75: 230: 53.42
+	Sp
		194782 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP41_SCHPO (1-243): 3.52e-74: 227: 40.74
+	Dm
		1250326 Q9VC93_DROME (7-988): 0: 943: 31.52		Q8T4A9_DROME (2-232): 2.05e-49: 168: 17.29
+	Sp
		252320 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP45_SCHPO (2-243): 3.75e-49: 164: 10.47
+	Dm
		1362699 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VW53_DROME (17-243): 1.28e-46: 159: 25.00
+	Dm
		1362694 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VGZ2_DROME (18-241): 9.51e-47: 157: 21.24
+	Sp
		740398 DIS3_SCHPO (5-972): 0: 941: 32.54		MTR3_SCHPO (17-232): 1.96e-46: 156: 25.23
+	Sc
		809596 RRP44_YEAST (2-971): 0: 893: 31.47		RRP41_YEAST (1-239): 2.42e-64: 202: 35.27
+	Sp
		194808 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP46_SCHPO (28-239): 1.76e-42: 145: 22.37
+	Sc
		860819 RRP44_YEAST (2-971): 0: 893: 31.47		RRP46_YEAST (25-242): 9.8e-41: 140: 19.83