HitPredict

Interactor 1: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Interactor 2: LHX3 (Q9UBR4)
LIM/homeobox protein Lhx3 (LIM homeobox protein 3)
Gene: LHX3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	9452425, 33961781, 35140242
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain, LIM~LIM
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0021520 - spinal cord motor neuron cell fate specification GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 359 Hs			1 397
+	Hs
		899935 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		LHX3_HUMAN (1-397): 1.88e-110: 331: 100.00
+	Mm
		839895 ISL1_MOUSE (14-358): 6.97e-87: 268: 73.91		LHX3_MOUSE (1-397): 6.84e-103: 311: 90.75
+	Hs
		899927 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		LMX1A_HUMAN (1-339): 2.26e-63: 209: 28.20
+	Hs
		238115 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		LMX1B_HUMAN (1-339): 4.26e-64: 212: 28.54
+	Hs
		822660 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		LHX1_HUMAN (31-396): 6.18e-62: 206: 32.21
+	Hs
		899916 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		ISL1_HUMAN (21-309): 5.65e-50: 173: 27.60
+	Dm
		114751 P92031_DROME (6-345): 6.08e-63: 211: 51.61		M9PD53_DROME (25-393): 1.56e-68: 227: 47.26
+	Dm
		1368258 Q9VJ37_DROME (6-345): 3.2e-63: 212: 52.15		Q9VJ00_DROME (25-393): 3.23e-68: 226: 47.26
+	Dm
		112552 Q9VJ37_DROME (6-345): 3.2e-63: 212: 52.15		M9NCY1_DROME (27-393): 7.37e-69: 224: 47.51
+	Hs
		1148484 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		LHX8_HUMAN (30-290): 3.86e-49: 171: 29.12
+	Hs
		1251421 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		LMO3_HUMAN (31-159): 1.12e-51: 171: 41.05
+	Hs
		638556 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		RBTN1_HUMAN (31-149): 1.03e-50: 169: 42.74
+	Hs
		899930 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		ISL2_HUMAN (21-321): 3.61e-46: 164: 27.75
+	Hs
		903764 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		LMO4_HUMAN (31-148): 2.3e-28: 110: 43.09
+	Hs
		1251463 LHX5_HUMAN (26-358): 1.02e-59: 199: 26.90		LMO3_HUMAN (31-159): 1.12e-51: 171: 41.05
+	Hs
		839800 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		LHX2_HUMAN (136-281): 4.68e-15: 77.9: 23.90
+	Hs
		899929 ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91		LHX4_HUMAN (8-83): 1.09e-13: 73.9: 25.00
+	Hs
		1281161 ISL2_HUMAN (1-359): 2.24e-85: 264: 100.00		LHX4_HUMAN (8-83): 1.09e-13: 73.9: 25.00
+	Mm
		864805 ISL2_MOUSE (1-359): 3.88e-85: 263: 98.61		LHX4_MOUSE (8-83): 1e-13: 73.9: 25.00