HitPredict

Interactor 1: PKP4 (Q99569)
Plakophilin-4 (p0071)
Gene: PKP4

Interactor 2: CTNA3 (Q9UI47)
Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein)
Gene: CTNNA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0005912 - adherens junction GO:0030057 - desmosome GO:0045296 - cadherin binding and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1192 Hs			1 895
+	Hs
		716755 PKP4_HUMAN (1-1192): 0: 1148: 100.00		CTNA1_HUMAN (7-891): 0: 992: 59.40
+	Hs
		1307400 PKP2_HUMAN (156-1014): 1.57e-160: 502: 24.78		CTNA3_HUMAN (1-895): 0: 1016: 100.00
+	Hs
		1355724 PKP3_HUMAN (218-1014): 2.04e-152: 478: 26.92		CTNA3_HUMAN (1-895): 0: 1016: 100.00
+	Hs
		716759 PKP2_HUMAN (156-1014): 1.57e-160: 502: 24.78		CTNA1_HUMAN (7-891): 0: 992: 59.40
+	Hs
		717407 CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00		CTNA3_HUMAN (1-895): 0: 1016: 100.00
+	Hs
		640706 CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00		CTNA2_HUMAN (2-891): 0: 1002: 57.66
+	Hs
		716609 CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00		CTNA1_HUMAN (7-891): 0: 992: 59.40
+	Mm
		640689 CTNB1_MOUSE (311-1123): 2.73e-149: 469: 16.00		CTNA1_MOUSE (7-891): 0: 986: 59.28
+	Rn
		1137286 CTNB1_RAT (311-1123): 6.52e-149: 468: 16.00		Q5U302_RAT (4-891): 0: 978: 58.95
+	Hs
		542474 PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54		CTNA3_HUMAN (1-895): 0: 1016: 100.00
+	Hs
		542192 PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54		CTNA2_HUMAN (2-891): 0: 1002: 57.66
+	Hs
		542214 PLAK_HUMAN (316-1101): 3.54e-125: 404: 16.54		CTNA1_HUMAN (7-891): 0: 992: 59.40
+	Mm
		640690 PLAK_MOUSE (316-1101): 1.54e-123: 400: 16.42		CTNA1_MOUSE (7-891): 0: 986: 59.28
+	Dm
		578618 ARM_DROME (301-1095): 4.62e-122: 399: 16.75		CTNA_DROME (7-891): 0: 930: 51.39
+	Ce
		954162 JAC1_CAEEL (453-1068): 2.33e-144: 469: 33.65		HMP1_CAEEL (9-894): 0: 808: 36.54
+	Hs
		239065 CTND1_HUMAN (26-872): 2.01e-72: 263: 13.69		CTNA1_HUMAN (7-891): 0: 992: 59.40
+	Hs
		716634 GDS1_HUMAN (530-972): 4.81e-75: 263: 16.70		CTNA1_HUMAN (7-891): 0: 992: 59.40
+	Ce
		60936 H2L2I2_CAEEL (356-1063): 8.2e-106: 351: 16.15		A5JYX3_CAEEL (9-894): 0: 805: 36.43
+	Ce
		218218 HMP2_CAEEL (385-1063): 4.09e-99: 332: 15.97		HMP1_CAEEL (9-894): 0: 808: 36.54
+	Hs
		575697 CTNB1_HUMAN (311-1123): 4.61e-149: 469: 16.00		VINC_HUMAN (20-615): 2.01e-62: 231: 15.93