HitPredict

Interactor 1: PHC2 (Q8IXK0)
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Gene: PHC2

Interactor 2: R4GMX3 (R4GMX3)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4)
Gene: COMMD3-BMI1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	25910212
Identification Methods	two hybrid bait and prey pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008270 - zinc ion binding GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 858 Hs			1 469
+	Hs
		765689 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		BMI1_HUMAN (144-469): 6.59e-150: 431: 100.00
+	Mm
		683132 PHC2_MOUSE (1-858): 1.29e-83: 288: 85.40		BMI1_MOUSE (144-469): 9.58e-147: 423: 96.93
+	Hs
		766101 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		PCGF2_HUMAN (144-463): 3.18e-116: 346: 61.36
+	Mm
		662912 PHC2_MOUSE (1-858): 1.29e-83: 288: 85.40		PCGF2_MOUSE (144-463): 2.28e-112: 336: 61.06
+	Hs
		765374 PHC1_HUMAN (57-858): 2.63e-43: 172: 27.06		BMI1_HUMAN (144-469): 6.59e-150: 431: 100.00
+	Hs
		1185920 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		PCGF3_HUMAN (147-371): 2.5e-67: 217: 34.73
+	Dr
		1317133 PHC2_DANRE (10-858): 1.43e-44: 175: 40.12		BMI1A_DANRE (144-469): 1.11e-123: 364: 81.29
+	Dr
		1274172 PHC2_DANRE (10-858): 1.43e-44: 175: 40.12		BMI1B_DANRE (144-465): 1.15e-120: 357: 77.23
+	Hs
		1312489 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		PCGF1_HUMAN (119-372): 7.54e-62: 203: 33.71
+	Hs
		1312485 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		RING2_HUMAN (113-375): 2.06e-59: 200: 15.39
+	Hs
		1312495 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		PCGF6_HUMAN (141-378): 1.35e-59: 200: 34.55
+	Hs
		766082 PHC1_HUMAN (57-858): 2.63e-43: 172: 27.06		PCGF2_HUMAN (144-463): 3.18e-116: 346: 61.36
+	Hs
		1286243 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		PCGF5_HUMAN (144-371): 5.1e-54: 183: 30.44
+	Mm
		1423709 PHC2_MOUSE (1-858): 1.29e-83: 288: 85.40		RING2_MOUSE (113-375): 1.58e-59: 200: 15.39
+	Hs
		1055822 PHC2_HUMAN (1-858): 4.48e-98: 327: 100.00		RING1_HUMAN (123-258): 6.51e-36: 139: 21.17
+	Mm
		205500 PHC2_MOUSE (1-858): 1.29e-83: 288: 85.40		RING1_MOUSE (123-258): 3.03e-36: 140: 21.17
+	Hs
		1006847 PHC1_HUMAN (57-858): 2.63e-43: 172: 27.06		PCGF3_HUMAN (147-371): 2.5e-67: 217: 34.73
+	Dr
		1281812 PHC2_DANRE (10-858): 1.43e-44: 175: 40.12		RING2_DANRE (113-375): 1.68e-57: 195: 15.39
+	Hs
		1006849 PHC1_HUMAN (57-858): 2.63e-43: 172: 27.06		Q5T8Z6_HUMAN (144-248): 3.83e-47: 160: 100.00
+	Hs
		1006842 PHC1_HUMAN (57-858): 2.63e-43: 172: 27.06		RING1_HUMAN (123-258): 6.51e-36: 139: 21.17