HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: ARRD3 (Q96B67)
Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
Gene: ARRDC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	37223976, 26490116, 29416926, 32296183, 23236378, unassigned1304, unassigned3799
Identification Methods	pull down, affinity chromatography technology, two hybrid, validated two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 414
+	Hs
		132178 WWP2_HUMAN (1-870): 0: 984: 100.00		ARRD2_HUMAN (1-411): 3.64e-128: 377: 53.16
+	Hs
		132169 WWP2_HUMAN (1-870): 0: 984: 100.00		ARRD4_HUMAN (4-411): 1.81e-123: 365: 51.10
+	Hs
		1384104 ITCH_HUMAN (1-870): 0: 899: 53.91		ARRD3_HUMAN (1-414): 2.21e-149: 431: 100.00
+	Hs
		132293 WWP2_HUMAN (1-870): 0: 984: 100.00		TXNIP_HUMAN (1-399): 5.12e-112: 335: 40.75
+	Hs
		1384128 WWP1_HUMAN (1-870): 0: 883: 58.27		ARRD3_HUMAN (1-414): 2.21e-149: 431: 100.00
+	Hs
		1348887 ITCH_HUMAN (1-870): 0: 899: 53.91		ARRD2_HUMAN (1-411): 3.64e-128: 377: 53.16
+	Hs
		1336056 ITCH_HUMAN (1-870): 0: 899: 53.91		ARRD4_HUMAN (4-411): 1.81e-123: 365: 51.10
+	Hs
		1348894 WWP1_HUMAN (1-870): 0: 883: 58.27		ARRD2_HUMAN (1-411): 3.64e-128: 377: 53.16
+	Hs
		1336069 WWP1_HUMAN (1-870): 0: 883: 58.27		ARRD4_HUMAN (4-411): 1.81e-123: 365: 51.10
+	Hs
		1394610 ITCH_HUMAN (1-870): 0: 899: 53.91		TXNIP_HUMAN (1-399): 5.12e-112: 335: 40.75
+	Hs
		1430204 WWP1_HUMAN (1-870): 0: 883: 58.27		TXNIP_HUMAN (1-399): 5.12e-112: 335: 40.75
+	Hs
		132163 WWP2_HUMAN (1-870): 0: 984: 100.00		ARRD1_HUMAN (3-412): 6.7e-68: 223: 21.43
+	Dm
		1476984 SUDX_DROME (14-870): 0: 845: 52.14		Q9VI00_DROME (16-412): 5.75e-99: 303: 27.23
+	Hs
		732673 ITCH_HUMAN (1-870): 0: 899: 53.91		ARRB2_HUMAN (12-375): 9.84e-71: 230: 12.53
+	Hs
		882546 ITCH_HUMAN (1-870): 0: 899: 53.91		ARRB1_HUMAN (12-377): 6.49e-70: 228: 13.41
+	Hs
		1327833 ITCH_HUMAN (1-870): 0: 899: 53.91		ARRD1_HUMAN (3-412): 6.7e-68: 223: 21.43
+	Mm
		1298171 ITCH_MOUSE (1-870): 0: 894: 55.73		ARRB2_MOUSE (12-358): 4.48e-69: 225: 12.06
+	Hs
		1327840 WWP1_HUMAN (1-870): 0: 883: 58.27		ARRD1_HUMAN (3-412): 6.7e-68: 223: 21.43
+	Dm
		1476963 SUDX_DROME (14-870): 0: 845: 52.14		Q9VHZ7_DROME (9-319): 2.5e-75: 245: 23.90
+	Dm
		1475270 SUDX_DROME (14-870): 0: 845: 52.14		Q9VGU4_DROME (12-309): 4.77e-62: 210: 22.30