Protein: ARRD4
Arrestin domain-containing protein 4

Gene: ARRD4, ARRDC4
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q8NCT1

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

719813

V2R
Vasopressin V2 receptor

1

17

Small-scale

0.665

High

132169

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

20

Small-scale

0.628

High

1336056

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.628

High

1336059

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

20

Small-scale

0.628

High

1336069

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

20

High-throughput

0.628

High

458447

ADRB2
Beta-2 adrenergic receptor

1

10

Small-scale

0.618

High

732648

ARRB2
Beta-arrestin-2

1

16

Small-scale

0.618

High

882532

ARRB1
Beta-arrestin-1

1

16

Small-scale

0.618

High

208539

PJA2
E3 ubiquitin-protein ligase Praja-2

1

6

High-throughput

0.536

High

220953

XPOT
Exportin-T

1

6

High-throughput

0.536

High

227924

MYO1B
Unconventional myosin-Ib

1

16

High-throughput

0.536

High

231733

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.536

High

273214

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

17

High-throughput

0.536

High

300016

CBPD
Carboxypeptidase D

1

1

High-throughput

0.536

High

318361

MYO1D
Unconventional myosin-Id

1

16

High-throughput

0.536

High

322744

RHBT3
Rho-related BTB domain-containing protein 3

1

2

High-throughput

0.536

High

334059

SMC2
Structural maintenance of chromosomes protein 2

1

4

High-throughput

0.536

High

336457

SVIL
Supervillin

1

7

High-throughput

0.536

High

342966

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.536

High

522701

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

4

High-throughput

0.536

High

543238

UBL4A
Ubiquitin-like protein 4A

1

20

High-throughput

0.536

High

637928

NF1
Neurofibromin

1

3

High-throughput

0.536

High

658737

JAK1
Tyrosine-protein kinase JAK1

1

9

High-throughput

0.536

High

681453

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.536

High

697595

PYR1
Multifunctional protein CAD

1

2

High-throughput

0.536

High

701193

PSB5
Proteasome subunit beta type-5

1

7

High-throughput

0.536

High

710366

EPHA2
Ephrin type-A receptor 2

1

8

High-throughput

0.536

High

787205

BMR1A
Bone morphogenetic protein receptor type-1A

1

4

High-throughput

0.536

High

856813

BAG6
Large proline-rich protein BAG6

1

20

High-throughput

0.536

High

861224

MAP1B
Microtubule-associated protein 1B

1

17

High-throughput

0.536

High

887568

PSB3
Proteasome subunit beta type-3

1

9

High-throughput

0.536

High

887695

PSB2
Proteasome subunit beta type-2

1

8

High-throughput

0.536

High

901947

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.536

High

933447

S12A2
Solute carrier family 12 member 2

1

2

High-throughput

0.536

High

968997

PRS8
26S proteasome regulatory subunit 8

1

8

High-throughput

0.536

High

1102209

ATM
Serine-protein kinase ATM

1

7

High-throughput

0.536

High

1102729

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

4

High-throughput

0.536

High

1120769

DSG2
Desmoglein-2

1

2

High-throughput

0.536

High

1204768

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

6

High-throughput

0.536

High

1272402

GET4
Golgi to ER traffic protein 4 homolog

1

3

High-throughput

0.536

High

1277504

MON2
Protein MON2 homolog

1

14

High-throughput

0.536

High

1278290

LRP10
Low-density lipoprotein receptor-related protein 10

1

4

High-throughput

0.536

High

1280348

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.536

High

1315812

AN13A
Ankyrin repeat domain-containing protein 13A

1

4

High-throughput

0.536

High

1336052

IPO4
Importin-4

1

20

High-throughput

0.536

High

1336054

GCN1
Stalled ribosome sensor GCN1

1

15

High-throughput

0.536

High

1336057

KI16B
Kinesin-like protein KIF16B

1

3

High-throughput

0.536

High

1336058

IPO9
Importin-9

1

12

High-throughput

0.536

High

1336072

AKIB1
Ankyrin repeat and IBR domain-containing protein 1

1

6

High-throughput

0.536

High

1336073

MYO6
Unconventional myosin-VI

1

10

High-throughput

0.536

High

1336077

LRP12
Low-density lipoprotein receptor-related protein 12

1

4

High-throughput

0.536

High

175398

PLXB2
Plexin-B2

1

0

High-throughput

0.513

High

390678

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.513

High

467279

MDR1
ATP-dependent translocase ABCB1

1

0

High-throughput

0.513

High

1336053

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.513

High

1336060

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

1336063

ABCA3
Phospholipid-transporting ATPase ABCA3

1

0

High-throughput

0.513

High

1336064

PELO
Protein pelota homolog

1

0

High-throughput

0.513

High

1336071

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

317894

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.489

High

667373

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

High-throughput

0.489

High

874177

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

1

High-throughput

0.489

High

933689

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

4

High-throughput

0.489

High

1098064

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

5

High-throughput

0.489

High

1147541

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.489

High

1216518

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

13

High-throughput

0.489

High

1336055

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

High-throughput

0.489

High

1336061

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

5

High-throughput

0.489

High

1336062

METH
Methionine synthase

1

1

High-throughput

0.489

High

1336067

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

High-throughput

0.489

High

1336070

SMC4
Structural maintenance of chromosomes protein 4

1

5

High-throughput

0.489

High

1336074

MAGD2
Melanoma-associated antigen D2

1

4

High-throughput

0.489

High

1336075

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

1

High-throughput

0.489

High

1336076

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.489

High

989760

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.479

High

1245045

TRI65
E3 ubiquitin-protein ligase TRIM65

1

4

Small-scale

0.479

High

1336068

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

4

Small-scale

0.479

High

270573

LRP4
Low-density lipoprotein receptor-related protein 4

1

3

High-throughput

0.445

High

538847

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

7

High-throughput

0.445

High

839482

PI4KA
Phosphatidylinositol 4-kinase alpha

1

14

High-throughput

0.445

High

174562

TRI66
Tripartite motif-containing protein 66

1

8

High-throughput

0.437

High

1195665

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

13

High-throughput

0.437

High

347180

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1336065

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.279

Low

1336066

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025