HitPredict

Interactor 1: KREM2 (Q8NCW0)
Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose)
Gene: KREMEN2

Interactor 2: KLK15 (Q9H2R5)
Kallikrein-15 (EC 3.4.21.-) (ACO protease)
Gene: KLK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CUB~Trypsin, Kringle~Trypsin
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 462 Hs			1 256
+	Hs
		1336113 KREM2_HUMAN (1-446): 1.62e-112: 341: 100.00		KLK5_HUMAN (5-256): 9.44e-97: 286: 40.55
+	Hs
		458003 BMP1_HUMAN (158-444): 2.31e-38: 150: 15.95		TRY2_HUMAN (1-256): 4.78e-113: 326: 43.02
+	Hs
		562758 BMP1_HUMAN (158-444): 2.31e-38: 150: 15.95		KLK15_HUMAN (1-256): 1.44e-112: 325: 100.00
+	Hs
		944924 NETO2_HUMAN (201-457): 6.65e-45: 165: 16.79		TMPS3_HUMAN (4-256): 2.48e-99: 298: 30.45
+	Hs
		562693 BMP1_HUMAN (158-444): 2.31e-38: 150: 15.95		KLK2_HUMAN (1-256): 1.43e-106: 310: 39.63
+	Hs
		164220 NRP1_HUMAN (119-372): 2.34e-34: 138: 14.33		HEPS_HUMAN (4-254): 2.77e-96: 290: 30.55
+	Hs
		366460 UROK_HUMAN (33-120): 6.44e-26: 111: 34.44		KLK1_HUMAN (1-256): 5.38e-105: 306: 37.64
+	Hs
		628403 ROR2_HUMAN (15-120): 1.5e-21: 100: 28.32		KLK2_HUMAN (1-256): 1.43e-106: 310: 39.63
+	Hs
		892146 PCOC2_HUMAN (171-331): 2.64e-27: 114: 18.75		KLK7_HUMAN (13-255): 1.09e-100: 295: 41.98
+	Hs
		437825 PCOC2_HUMAN (171-331): 2.64e-27: 114: 18.75		HEPS_HUMAN (4-254): 2.77e-96: 290: 30.55
+	Hs
		366520 TPA_HUMAN (20-133): 5.65e-23: 103: 31.03		HEPS_HUMAN (4-254): 2.77e-96: 290: 30.55
+	Hs
		239281 HGFL_HUMAN (35-204): 1.24e-15: 81.5: 22.81		TM11D_HUMAN (19-252): 1.13e-97: 293: 33.61
+	Mm
		204726 NRP2_MOUSE (99-387): 8.59e-39: 151: 15.62		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40
+	Hs
		210794 DMBT1_HUMAN (98-336): 2.5e-25: 111: 15.16		KLK10_HUMAN (25-256): 3.94e-60: 192: 41.67
+	Mm
		398330 NRP1_MOUSE (178-372): 6.87e-34: 137: 18.35		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40
+	Mm
		398714 C1RB_MOUSE (225-446): 3.93e-24: 107: 15.04		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40
+	Mm
		398047 TPA_MOUSE (34-132): 3.46e-22: 101: 31.68		CFAD_MOUSE (12-256): 1.1e-45: 155: 37.40