Protein: KREM2
Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose)

Gene: KREM2, KREMEN2
Organism: Homo sapiens
Interactions: 27
UniProt ID: Q8NCW0

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0016055 - Wnt signaling pathway
GO:0030279 - negative regulation of ossification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168436

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.691

High

321725

DKK1
Dickkopf-related protein 1

1

1

High-throughput

0.691

High

1336111

BTNL2
Butyrophilin-like protein 2

1

5

High-throughput

0.691

High

479069

CEL3A
Chymotrypsin-like elastase family member 3A

1

13

High-throughput

0.618

High

1336104

OIT3
Oncoprotein-induced transcript 3 protein

1

13

High-throughput

0.618

High

1336108

KLK15
Kallikrein-15

1

17

High-throughput

0.618

High

570700

EDN3
Endothelin-3

2

1

High-throughput

0.601

High

144106

WNT7A
Protein Wnt-7a

1

4

High-throughput

0.536

High

426119

PPB1
Alkaline phosphatase, placental type

1

1

High-throughput

0.536

High

506879

CFC1
Cryptic protein

1

2

High-throughput

0.536

High

1030196

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.536

High

1336110

CLC2D
C-type lectin domain family 2 member D

1

10

High-throughput

0.536

High

1336106

HPLN3
Hyaluronan and proteoglycan link protein 3

1

5

High-throughput

0.514

High

1336113

KLK5
Kallikrein-5

1

20

High-throughput

0.514

High

1336107

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.513

High

191452

SIA8E
Alpha-2,8-sialyltransferase 8E

1

4

High-throughput

0.489

High

342626

LY86
Lymphocyte antigen 86

1

4

High-throughput

0.489

High

567924

PRG2
Bone marrow proteoglycan

1

7

High-throughput

0.489

High

889932

VEGFB
Vascular endothelial growth factor B

1

7

High-throughput

0.489

High

1245884

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.489

High

1336105

ESPB1
Epididymal sperm-binding protein 1

1

13

High-throughput

0.489

High

1336109

FBX6
F-box only protein 6

1

5

High-throughput

0.489

High

155957

SOCS3
Suppressor of cytokine signaling 3

1

11

Small-scale

0.437

High

170882

CLGN
Calmegin

1

10

High-throughput

0.407

High

1336112

PRG3
Proteoglycan 3

1

12

High-throughput

0.407

High

1194693

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

385986

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025