HitPredict

Interactor 1: CHM4 (Q8T0Q4)
Charged multivesicular body protein 4 (CHMP4) (ESCRT-III complex core component shrb) (Protein Shrub)
Gene: shrb

Interactor 2: Q9VRY6 (Q9VRY6)
IST1 homolog (Charged multivesicular body protein 8)
Gene: Ist1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	38944040
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ist1~Snf7
Common GO terms	GO:0032509 - endosome transport via multivesicular body sorting pathway
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 226 Dm			1 417
+	Dm
		122092 CHM4_DROME (1-226): 7.68e-50: 163: 100.00		M9PHL4_DROME (1-417): 2.61e-122: 361: 92.09
+	Dm
		1485262 CHMP5_DROME (4-210): 1.84e-35: 126: 23.83		Q9VRY6_DROME (1-417): 5.42e-131: 385: 100.00
+	Dm
		1484930 Q9VRJ5_DROME (3-203): 3.88e-31: 115: 15.84		Q9VRY6_DROME (1-417): 5.42e-131: 385: 100.00
+	Dm
		1469212 Q9VBI3_DROME (4-204): 1.94e-28: 109: 13.37		Q9VRY6_DROME (1-417): 5.42e-131: 385: 100.00
+	Dm
		1482282 Q9VN02_DROME (1-223): 1.97e-27: 106: 15.18		Q9VRY6_DROME (1-417): 5.42e-131: 385: 100.00
+	Dm
		122106 CHMP5_DROME (4-210): 1.84e-35: 126: 23.83		M9PHL4_DROME (1-417): 2.61e-122: 361: 92.09
+	Ce
		112134 Q18886_CAEEL (1-226): 4.85e-47: 156: 55.51		G5EDV6_CAEEL (2-417): 2.04e-109: 330: 38.89
+	Dm
		122105 Q9VRJ5_DROME (3-203): 3.88e-31: 115: 15.84		M9PHL4_DROME (1-417): 2.61e-122: 361: 92.09
+	Dm
		122098 Q9VBI3_DROME (4-204): 1.94e-28: 109: 13.37		M9PHL4_DROME (1-417): 2.61e-122: 361: 92.09
+	Dm
		122101 Q9VN02_DROME (1-223): 1.97e-27: 106: 15.18		M9PHL4_DROME (1-417): 2.61e-122: 361: 92.09
+	Ce
		112131 O16458_CAEEL (4-211): 4.38e-32: 117: 21.86		G5EDV6_CAEEL (2-417): 2.04e-109: 330: 38.89
+	Ce
		112135 Q9BL60_CAEEL (10-217): 1.95e-29: 110: 26.79		G5EDV6_CAEEL (2-417): 2.04e-109: 330: 38.89
+	Hs
		925681 CHM4B_HUMAN (1-225): 1.24e-38: 134: 56.96		IST1_HUMAN (1-416): 4.26e-96: 294: 41.73
+	Hs
		925688 CHMP5_HUMAN (4-200): 4.32e-37: 131: 22.06		IST1_HUMAN (1-416): 4.26e-96: 294: 41.73
+	Sc
		781331 DID4_YEAST (1-219): 9.07e-34: 122: 13.90		IST1_YEAST (6-178): 2.05e-58: 194: 31.49
+	Sc
		923808 VPS20_YEAST (12-218): 4.28e-32: 117: 21.20		IST1_YEAST (6-178): 2.05e-58: 194: 31.49
+	Sc
		815040 SNF7_YEAST (2-223): 1.25e-27: 106: 33.33		IST1_YEAST (6-178): 2.05e-58: 194: 31.49
+	Sc
		923807 VPS60_YEAST (4-214): 3.08e-24: 97.9: 19.11		IST1_YEAST (6-178): 2.05e-58: 194: 31.49