HitPredict

Interactor 1: M9PHL4 (M9PHL4)
IST1 homolog (Charged multivesicular body protein 8)
Gene: Ist1

Interactor 2: CHMP5 (Q9VVI9)
Charged multivesicular body protein 5 (Vacuolar protein-sorting-associated protein 60)
Gene: Vps60

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ist1~Snf7
Common GO terms	GO:0015031 - protein transport GO:0032509 - endosome transport via multivesicular body sorting pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 384 Dm			1 226
+	Dm
		1485262 Q9VRY6_DROME (1-384): 3.89e-124: 366: 91.85		CHMP5_DROME (1-226): 1.87e-46: 155: 100.00
+	Dm
		122092 M9PHL4_DROME (1-384): 3.64e-137: 398: 100.00		CHM4_DROME (7-222): 1.35e-30: 114: 24.42
+	Dm
		122101 M9PHL4_DROME (1-384): 3.64e-137: 398: 100.00		Q9VN02_DROME (4-219): 4.79e-29: 110: 12.96
+	Dm
		122098 M9PHL4_DROME (1-384): 3.64e-137: 398: 100.00		Q9VBI3_DROME (7-208): 7.07e-25: 100: 17.82
+	Dm
		122105 M9PHL4_DROME (1-384): 3.64e-137: 398: 100.00		Q9VRJ5_DROME (2-211): 2.75e-25: 100: 13.33
+	Dm
		1345402 Q9VRY6_DROME (1-384): 3.89e-124: 366: 91.85		CHM4_DROME (7-222): 1.35e-30: 114: 24.42
+	Dm
		1482282 Q9VRY6_DROME (1-384): 3.89e-124: 366: 91.85		Q9VN02_DROME (4-219): 4.79e-29: 110: 12.96
+	Hs
		925688 IST1_HUMAN (1-383): 6.85e-109: 325: 46.13		CHMP5_HUMAN (1-222): 1.85e-43: 147: 63.06
+	Dm
		1469212 Q9VRY6_DROME (1-384): 3.89e-124: 366: 91.85		Q9VBI3_DROME (7-208): 7.07e-25: 100: 17.82
+	Dm
		1484930 Q9VRY6_DROME (1-384): 3.89e-124: 366: 91.85		Q9VRJ5_DROME (2-211): 2.75e-25: 100: 13.33
+	Ce
		112131 G5EDV6_CAEEL (2-384): 2.98e-98: 300: 38.01		O16458_CAEEL (1-221): 5.74e-35: 125: 54.51
+	Hs
		925681 IST1_HUMAN (1-383): 6.85e-109: 325: 46.13		CHM4B_HUMAN (15-218): 3.53e-25: 100: 23.42
+	Ce
		112134 G5EDV6_CAEEL (2-384): 2.98e-98: 300: 38.01		Q18886_CAEEL (2-218): 1.6e-33: 121: 22.94
+	Ce
		112135 G5EDV6_CAEEL (2-384): 2.98e-98: 300: 38.01		Q9BL60_CAEEL (1-211): 2.36e-24: 97.6: 18.06
+	Sc
		781331 IST1_YEAST (6-226): 3.95e-62: 203: 25.32		DID4_YEAST (7-225): 1.43e-29: 111: 13.84
+	Sc
		923807 IST1_YEAST (6-226): 3.95e-62: 203: 25.32		VPS60_YEAST (1-207): 2.01e-29: 111: 32.30
+	Sc
		923808 IST1_YEAST (6-226): 3.95e-62: 203: 25.32		VPS20_YEAST (6-223): 7.56e-27: 104: 19.09
+	Sc
		815040 IST1_YEAST (6-226): 3.95e-62: 203: 25.32		SNF7_YEAST (3-211): 3.14e-25: 100: 24.53
+	Sc
		864573 IST1_YEAST (6-226): 3.95e-62: 203: 25.32		YJE9_YEAST (11-150): 4.78e-09: 57.5: 15.13