HitPredict

Interactor 1: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Interactor 2: ES8L1 (Q8TE68)
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)
Gene: EPS8L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Guanylate_kin~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1919 Hs			1 723
+	Mm
		1064404 DLG4_MOUSE (1177-1916): 1.49e-154: 495: 19.44		EPS8_MOUSE (3-716): 0: 753: 35.60
+	Hs
		440154 DLG5_HUMAN (1-1919): 0: 879: 100.00		LCK_HUMAN (417-701): 3.52e-67: 232: 15.36
+	Hs
		463667 DLG5_HUMAN (1-1919): 0: 879: 100.00		LYN_HUMAN (451-704): 2.55e-55: 199: 15.89
+	Hs
		222156 DLG5_HUMAN (1-1919): 0: 879: 100.00		NCK2_HUMAN (478-605): 1.6e-36: 143: 23.70
+	Hs
		594054 DLG5_HUMAN (1-1919): 0: 879: 100.00		NCK1_HUMAN (478-605): 5.22e-32: 130: 22.96
+	Mm
		440284 DLG1_MOUSE (1123-1916): 1.57e-160: 518: 20.16		LCK_MOUSE (422-701): 3.17e-65: 226: 15.29
+	Hs
		440052 DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14		LCK_HUMAN (417-701): 3.52e-67: 232: 15.36
+	Rn
		723904 DLG4_RAT (1177-1916): 7.78e-156: 499: 19.57		SRC_RAT (423-704): 1.37e-60: 214: 13.60
+	Mm
		431355 DLG4_MOUSE (1177-1916): 1.49e-154: 495: 19.44		SRC_MOUSE (423-704): 7.42e-59: 210: 13.60
+	Hs
		463488 DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14		LYN_HUMAN (451-704): 2.55e-55: 199: 15.89
+	Hs
		440486 DLG4_HUMAN (1177-1916): 8.05e-155: 496: 19.44		FYN_HUMAN (430-704): 9.82e-56: 201: 13.07
+	Mm
		237076 DLG4_MOUSE (1177-1916): 1.49e-154: 495: 19.44		NCK2_MOUSE (380-601): 3.74e-10: 64.5: 14.46
+	Hs
		557298 MPP2_HUMAN (1419-1919): 9.89e-105: 350: 13.41		SRC_HUMAN (423-704): 1.44e-57: 206: 13.60
+	Rn
		76720 PALS1_RAT (1500-1916): 5.96e-100: 339: 18.78		SRC_RAT (423-704): 1.37e-60: 214: 13.60
+	Hs
		463806 PALS2_HUMAN (1396-1919): 2.59e-106: 353: 14.80		LYN_HUMAN (451-704): 2.55e-55: 199: 15.89
+	Ce
		111354 LIN2_CAEEL (1236-1919): 2.27e-104: 361: 14.75		G5ED33_CAEEL (477-715): 5.88e-47: 181: 25.25
+	Hs
		440107 MPP7_HUMAN (1327-1437): 1.62e-09: 64.7: 23.89		LCK_HUMAN (417-701): 3.52e-67: 232: 15.36
+	Hs
		463569 MPP7_HUMAN (1327-1437): 1.62e-09: 64.7: 23.89		LYN_HUMAN (451-704): 2.55e-55: 199: 15.89
+	Hs
		222222 ZO2_HUMAN (1347-1499): 3.2e-09: 64.3: 15.06		NCK2_HUMAN (478-605): 1.6e-36: 143: 23.70