HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Guanylate_kin~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0008285 - negative regulation of cell population proliferation GO:0014069 - postsynaptic density GO:0030159 - signaling receptor complex adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 1919
+	Hs
		594054 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		463667 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Hs
		440154 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		DLG5_HUMAN (1-1919): 0: 879: 100.00
+	Mm
		237076 NCK2_MOUSE (1-380): 5.85e-94: 287: 96.05		DLG4_MOUSE (1177-1916): 1.49e-154: 495: 19.44
+	Mm
		440284 LCK_MOUSE (3-205): 9.15e-20: 92.5: 16.59		DLG1_MOUSE (1123-1916): 1.57e-160: 518: 20.16
+	Hs
		699724 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Hs
		136379 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Hs
		463488 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Hs
		440486 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		DLG4_HUMAN (1177-1916): 8.05e-155: 496: 19.44
+	Hs
		440052 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		DLG1_HUMAN (1122-1916): 1.67e-154: 501: 20.14
+	Rn
		723904 SRC_RAT (6-155): 4.02e-19: 91: 17.11		DLG4_RAT (1177-1916): 7.78e-156: 499: 19.57
+	Mm
		431355 SRC_MOUSE (6-155): 4.82e-19: 90.6: 17.11		DLG4_MOUSE (1177-1916): 1.49e-154: 495: 19.44
+	Hs
		987532 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		DLG4_HUMAN (1177-1916): 8.05e-155: 496: 19.44
+	Mm
		1221224 GRB2_MOUSE (1-60): 2.89e-18: 84.4: 27.87		DLG4_MOUSE (1177-1916): 1.49e-154: 495: 19.44
+	Hs
		463806 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		PALS2_HUMAN (1396-1919): 2.59e-106: 353: 14.80
+	Hs
		557298 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		MPP2_HUMAN (1419-1919): 9.89e-105: 350: 13.41
+	Rn
		76720 SRC_RAT (6-155): 4.02e-19: 91: 17.11		PALS1_RAT (1500-1916): 5.96e-100: 339: 18.78
+	Hs
		222222 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		ZO2_HUMAN (1347-1499): 3.2e-09: 64.3: 15.06
+	Hs
		463569 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MPP7_HUMAN (1327-1437): 1.62e-09: 64.7: 23.89
+	Hs
		440107 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MPP7_HUMAN (1327-1437): 1.62e-09: 64.7: 23.89