HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: CE128 (Q6ZU80)
Centrosomal protein of 128 kDa (Cep128)
Gene: CEP128

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24613305
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005814 - centriole
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 970 Hs			1 1094
+	Hs
		136129 PLK4_HUMAN (1-970): 0: 1040: 100.00		CP250_HUMAN (1-978): 2.05e-37: 155: 11.68
+	Hs
		270744 ROCK2_HUMAN (5-774): 1.36e-144: 467: 16.08		ROCK2_HUMAN (187-807): 2.24e-12: 73.9: 23.21
+	Rn
		97302 ROCK2_RAT (5-774): 1.75e-139: 453: 16.08		CTRO_RAT (586-1041): 9.93e-16: 84.9: 15.13
+	Bt
		1177132 ROCK2_BOVIN (5-774): 8.03e-144: 465: 16.08		ROCK2_BOVIN (187-807): 2.23e-11: 70.5: 23.07
+	Hs
		270810 ROCK2_HUMAN (5-774): 1.36e-144: 467: 16.08		EEA1_HUMAN (1-300): 9.18e-10: 65.1: 10.00
+	Hs
		270804 ROCK1_HUMAN (5-620): 1.22e-134: 439: 19.42		ROCK2_HUMAN (187-807): 2.24e-12: 73.9: 23.21
+	Hs
		772782 ROCK1_HUMAN (5-620): 1.22e-134: 439: 19.42		MYH9_HUMAN (3-384): 8.98e-12: 72.1: 10.35
+	Hs
		920058 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		CE128_HUMAN (1-1094): 4.13e-79: 283: 100.00
+	Hs
		170207 AURKA_HUMAN (9-273): 3.29e-53: 193: 37.74		CE128_HUMAN (1-1094): 4.13e-79: 283: 100.00
+	Hs
		1365604 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		MY18A_HUMAN (271-1014): 6.42e-28: 124: 13.96
+	Hs
		776870 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH11_HUMAN (349-1092): 9.04e-35: 147: 12.42
+	Hs
		776845 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		MYH11_HUMAN (349-1092): 9.04e-35: 147: 12.42
+	Hs
		773248 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		MYH10_HUMAN (342-1092): 1.42e-31: 136: 13.98
+	Hs
		556967 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH7_HUMAN (2-713): 5.94e-30: 131: 13.17
+	Hs
		1462713 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH4_HUMAN (517-1091): 2.83e-25: 115: 12.24
+	Hs
		563079 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH8_HUMAN (1-554): 2.41e-20: 100: 11.42
+	Hs
		157728 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		CTRO_HUMAN (141-628): 3.18e-15: 83.1: 13.00
+	Hs
		772956 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		MYH9_HUMAN (3-384): 8.98e-12: 72.1: 10.35
+	Hs
		587768 AURKB_HUMAN (9-269): 1.35e-49: 181: 36.78		DESP_HUMAN (169-971): 2.19e-10: 67.4: 19.90
+	Hs
		556888 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH1_HUMAN (756-1092): 9.6e-10: 65.1: 11.30