HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12052866
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, SH2~SOCS_box
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 728 Hs			1 535
+	Hs
		156060 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		SOCS6_HUMAN (1-535): 0: 714: 100.00
+	Hs
		136264 P85B_HUMAN (1-728): 0: 541: 100.00		HCK_HUMAN (236-495): 1.41e-60: 210: 15.16
+	Hs
		136254 P85B_HUMAN (1-728): 0: 541: 100.00		LCK_HUMAN (258-495): 2.35e-55: 195: 17.20
+	Hs
		136255 P85B_HUMAN (1-728): 0: 541: 100.00		FYN_HUMAN (321-506): 1.75e-51: 185: 15.39
+	Hs
		136276 P85B_HUMAN (1-728): 0: 541: 100.00		SRC_HUMAN (258-495): 1.88e-51: 185: 15.32
+	Hs
		136260 P85B_HUMAN (1-728): 0: 541: 100.00		LYN_HUMAN (266-495): 8.96e-47: 172: 14.05
+	Hs
		136236 P85B_HUMAN (1-728): 0: 541: 100.00		SOCS1_HUMAN (379-535): 5.82e-42: 151: 26.75
+	Hs
		136417 P85B_HUMAN (1-728): 0: 541: 100.00		P55G_HUMAN (380-505): 2.86e-19: 92.5: 26.19
+	Hs
		136297 P85B_HUMAN (1-728): 0: 541: 100.00		P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89
+	Hs
		473453 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		HCK_HUMAN (236-495): 1.41e-60: 210: 15.16
+	Hs
		440656 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		FYN_HUMAN (321-506): 1.75e-51: 185: 15.39
+	Hs
		463181 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		YES_HUMAN (321-495): 5.01e-51: 185: 14.67
+	Hs
		557409 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		SRC_HUMAN (258-495): 1.88e-51: 185: 15.32
+	Hs
		902870 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		BLK_HUMAN (301-495): 1.88e-47: 174: 16.13
+	Hs
		463686 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		LYN_HUMAN (266-495): 8.96e-47: 172: 14.05
+	Hs
		594065 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		NCK1_HUMAN (188-466): 1.55e-46: 168: 15.46
+	Hs
		1360859 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		SOCS4_HUMAN (370-535): 4.02e-39: 149: 36.53
+	Hs
		699816 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89
+	Dm
		1466640 SRC42_DROME (551-727): 4.13e-35: 142: 22.78		SRC42_DROME (277-502): 2.59e-59: 206: 18.67