Protein: SOCS4
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)

Gene: SOCS4
Organism: Homo sapiens
Interactions: 35
UniProt ID: Q8WXH5

Gene Ontology (top 5):
GO:0007175 - negative regulation of epidermal growth factor-activated receptor activity
GO:0016567 - protein ubiquitination
GO:0019221 - cytokine-mediated signaling pathway
GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1360860

CUL5
Cullin-5

4

20

High-throughput

0.895

High

1147075

ELOC
Elongin-C

3

10

Small-scale

0.821

High

987803

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.732

High

1360859

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.732

High

1060799

ACK1
Activated CDC42 kinase 1

2

20

High-throughput

0.686

High

1325296

PALS1
Protein PALS1

2

16

High-throughput

0.686

High

1360862

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

20

High-throughput

0.634

High

253369

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

532093

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.618

High

363635

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.609

High

1360866

RBX2
RING-box protein 2

2

14

High-throughput

0.601

High

1147221

ELOB
Elongin-B

2

11

Small-scale

0.584

High

1360861

RET7
Retinoid-binding protein 7

2

4

High-throughput

0.579

High

220285

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.573

High

1358976

TEKT4
Tektin-4

2

2

High-throughput

0.553

High

1360863

LDH6B
L-lactate dehydrogenase A-like 6B

2

1

High-throughput

0.542

High

216764

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

109478

G5E9A7
DM1 locus, WD repeat containing

1

12

High-throughput

0.470

High

843815

HD
Huntingtin

1

7

High-throughput

0.470

High

1279669

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

16

High-throughput

0.470

High

1360703

JPH3
Junctophilin-3

1

4

High-throughput

0.470

High

221382

SPY1
Protein sprouty homolog 1

1

8

High-throughput

0.439

High

407769

VWF
von Willebrand factor

1

3

High-throughput

0.439

High

652549

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

19

High-throughput

0.439

High

1360865

MDFIC
MyoD family inhibitor domain-containing protein

1

1

High-throughput

0.439

High

1125169

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

17

High-throughput

0.437

High

1360867

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.437

High

1227160

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.407

High

295419

CNMD
Leukocyte cell-derived chemotaxin 1

2

0

High-throughput

0.310

High

117011

J3KQ12
Seipin

1

0

High-throughput

0.268

Low

184886

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.268

Low

834345

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.268

Low

1360864

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.268

Low

1313630

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

1

0

High-throughput

0.251

Low

337230

LCA5L
Lebercilin-like protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025