HitPredict

Interactor 1: MAK11 (P20484)
Protein MAK11 (Maintenance of killer protein 11)
Gene: MAK11

Interactor 2: HAS1 (Q03532)
ATP-dependent RNA helicase HAS1 (EC 3.6.4.13) (Helicase associated with SET1 protein 1)
Gene: HAS1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	31511893, 17308036, 37968396, 16429126
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0005730 - nucleolus GO:0042273 - ribosomal large subunit biogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 414 Sc			1 505
+	Sc
		630886 NLE1_YEAST (1-220): 7.03e-38: 145: 16.03		HAS1_YEAST (1-505): 1.8e-165: 479: 100.00
+	Hs
		1271700 FBW1A_HUMAN (40-381): 1.28e-62: 213: 15.10		DDX17_HUMAN (4-478): 1.71e-134: 407: 29.31
+	Hs
		571638 FBW1A_HUMAN (40-381): 1.28e-62: 213: 15.10		DDX5_HUMAN (4-449): 2.8e-131: 395: 30.22
+	Hs
		134256 FBW1A_HUMAN (40-381): 1.28e-62: 213: 15.10		DDX3X_HUMAN (4-428): 1.25e-126: 385: 27.77
+	Hs
		181721 POC1A_HUMAN (80-411): 1.19e-62: 208: 14.67		DDX3Y_HUMAN (4-434): 8.05e-126: 383: 26.95
+	Hs
		1271615 FBXW7_HUMAN (135-411): 3.75e-47: 173: 13.17		DDX17_HUMAN (4-478): 1.71e-134: 407: 29.31
+	Hs
		134154 FBXW7_HUMAN (135-411): 3.75e-47: 173: 13.17		DDX3X_HUMAN (4-428): 1.25e-126: 385: 27.77
+	Sc
		594025 MAK11_YEAST (1-414): 1.65e-94: 291: 100.00		DRS1_YEAST (26-394): 3.8e-72: 245: 38.32
+	Sc
		594017 MAK11_YEAST (1-414): 1.65e-94: 291: 100.00		SPB4_YEAST (56-488): 1.9e-61: 213: 33.41
+	Hs
		903549 WDR5_HUMAN (269-411): 1.15e-16: 82.2: 11.11		DDX18_HUMAN (2-492): 3.3e-139: 418: 59.76
+	Hs
		134246 FBW1B_HUMAN (39-201): 1.65e-25: 110: 22.67		DDX3X_HUMAN (4-428): 1.25e-126: 385: 27.77
+	Hs
		903410 WDR5_HUMAN (269-411): 1.15e-16: 82.2: 11.11		DDX17_HUMAN (4-478): 1.71e-134: 407: 29.31
+	Hs
		1271679 NLE1_HUMAN (268-411): 1.73e-15: 79.9: 15.23		DDX17_HUMAN (4-478): 1.71e-134: 407: 29.31
+	Hs
		571382 WDR5_HUMAN (269-411): 1.15e-16: 82.2: 11.11		DDX5_HUMAN (4-449): 2.8e-131: 395: 30.22
+	Hs
		133956 WDR5_HUMAN (269-411): 1.15e-16: 82.2: 11.11		DDX3X_HUMAN (4-428): 1.25e-126: 385: 27.77
+	Sc
		630853 NLE1_YEAST (1-220): 7.03e-38: 145: 16.03		DRS1_YEAST (26-394): 3.8e-72: 245: 38.32
+	Sc
		630846 NLE1_YEAST (1-220): 7.03e-38: 145: 16.03		SPB4_YEAST (56-488): 1.9e-61: 213: 33.41
+	Hs
		903437 WDR5_HUMAN (269-411): 1.15e-16: 82.2: 11.11		DDX27_HUMAN (44-441): 4.37e-71: 243: 37.04
+	Hs
		903507 WDR5_HUMAN (269-411): 1.15e-16: 82.2: 11.11		DDX47_HUMAN (1-411): 5.57e-74: 242: 36.96
+	Hs
		1292666 NLE1_HUMAN (268-411): 1.73e-15: 79.9: 15.23		DDX27_HUMAN (44-441): 4.37e-71: 243: 37.04