HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29991678
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3K_P85_iSH2~SH2, SH2~SOCS_box
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 728 Hs			1 211
+	Hs
		136254 P85B_HUMAN (1-728): 0: 541: 100.00		LCK_HUMAN (4-194): 1.14e-38: 141: 13.46
+	Hs
		136255 P85B_HUMAN (1-728): 0: 541: 100.00		FYN_HUMAN (64-194): 7.24e-37: 136: 18.44
+	Hs
		136229 P85B_HUMAN (1-728): 0: 541: 100.00		SOCS6_HUMAN (67-209): 2.22e-35: 132: 26.22
+	Hs
		136362 P85B_HUMAN (1-728): 0: 541: 100.00		GRB2_HUMAN (52-181): 1.5e-35: 126: 16.79
+	Hs
		136417 P85B_HUMAN (1-728): 0: 541: 100.00		P55G_HUMAN (79-179): 6.12e-24: 100: 21.91
+	Hs
		136297 P85B_HUMAN (1-728): 0: 541: 100.00		P85A_HUMAN (53-180): 1.36e-23: 99.7: 20.00
+	Hs
		1360859 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		SOCS4_HUMAN (3-210): 9.85e-43: 150: 18.98
+	Hs
		440656 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		FYN_HUMAN (64-194): 7.24e-37: 136: 18.44
+	Hs
		597902 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		FER_HUMAN (4-176): 4.06e-36: 136: 17.58
+	Hs
		156060 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		SOCS6_HUMAN (67-209): 2.22e-35: 132: 26.22
+	Hs
		463181 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		YES_HUMAN (64-196): 3.83e-35: 131: 16.08
+	Hs
		594065 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		NCK1_HUMAN (17-175): 4.03e-36: 131: 21.25
+	Hs
		987808 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		GRB2_HUMAN (52-181): 1.5e-35: 126: 16.79
+	Hs
		699816 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		P85A_HUMAN (53-180): 1.36e-23: 99.7: 20.00
+	Dm
		1466640 SRC42_DROME (551-727): 4.13e-35: 142: 22.78		SRC42_DROME (64-202): 6.26e-38: 139: 19.44
+	Hs
		222026 TXK_HUMAN (550-727): 2.67e-33: 137: 23.24		NCK2_HUMAN (2-175): 1.5e-38: 138: 19.77
+	Hs
		155921 TXK_HUMAN (550-727): 2.67e-33: 137: 23.24		SOCS3_HUMAN (39-207): 1.95e-39: 136: 27.73
+	Hs
		156012 TXK_HUMAN (550-727): 2.67e-33: 137: 23.24		SOCS6_HUMAN (67-209): 2.22e-35: 132: 26.22
+	Hs
		699629 TXK_HUMAN (550-727): 2.67e-33: 137: 23.24		P85A_HUMAN (53-180): 1.36e-23: 99.7: 20.00