HitPredict

Interactor 1: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Interactor 2: KLF12 (Q9Y4X4)
Krueppel-like factor 12 (Transcriptional repressor AP-2rep)
Gene: KLF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	16189514, 32296183, 35140242, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 402
+	Hs
		339827 EHMT2_HUMAN (21-1210): 0: 903: 100.00		KLF8_HUMAN (38-399): 1.76e-105: 317: 44.11
+	Hs
		59219 A2ABF9_HUMAN (12-1210): 0: 909: 99.75		KLF3_HUMAN (20-402): 1.84e-72: 231: 38.48
+	Hs
		944723 EHMT2_HUMAN (21-1210): 0: 903: 100.00		KLF3_HUMAN (20-402): 1.84e-72: 231: 38.48
+	Hs
		1396289 EHMT2_HUMAN (21-1210): 0: 903: 100.00		KLF6_HUMAN (308-400): 3.26e-48: 167: 79.57
+	Hs
		1118758 EHMT2_HUMAN (21-1210): 0: 903: 100.00		KLF5_HUMAN (296-399): 7.16e-45: 162: 76.92
+	Hs
		1396322 EHMT2_HUMAN (21-1210): 0: 903: 100.00		KLF15_HUMAN (303-399): 3.46e-32: 127: 56.70
+	Hs
		1396296 EHMT2_HUMAN (21-1210): 0: 903: 100.00		KLF16_HUMAN (317-399): 2.05e-29: 116: 65.06
+	Hs
		1436932 EHMT1_HUMAN (1-1209): 0: 666: 45.16		KLF12_HUMAN (1-402): 9.36e-118: 350: 100.00
+	Hs
		339861 EHMT1_HUMAN (1-1209): 0: 666: 45.16		KLF8_HUMAN (38-399): 1.76e-105: 317: 44.11
+	Hs
		1118667 EHMT2_HUMAN (21-1210): 0: 903: 100.00		KLF9_HUMAN (336-399): 6.96e-09: 58.2: 45.46
+	Hs
		944745 EHMT1_HUMAN (1-1209): 0: 666: 45.16		KLF3_HUMAN (20-402): 1.84e-72: 231: 38.48
+	Hs
		1436927 EHMT1_HUMAN (1-1209): 0: 666: 45.16		KLF15_HUMAN (303-399): 3.46e-32: 127: 56.70
+	Hs
		1416913 EHMT1_HUMAN (1-1209): 0: 666: 45.16		KLF16_HUMAN (317-399): 2.05e-29: 116: 65.06
+	Hs
		944743 SUV92_HUMAN (928-1177): 2.73e-85: 285: 35.93		KLF3_HUMAN (20-402): 1.84e-72: 231: 38.48
+	Hs
		216557 SUV91_HUMAN (863-1177): 6.62e-88: 292: 31.71		KLF15_HUMAN (303-399): 3.46e-32: 127: 56.70
+	Hs
		216395 SUV91_HUMAN (863-1177): 6.62e-88: 292: 31.71		ZN165_HUMAN (150-401): 1.73e-29: 121: 15.73
+	Hs
		1311385 ANKH1_HUMAN (709-1047): 1.35e-35: 150: 16.86		KLF6_HUMAN (308-400): 3.26e-48: 167: 79.57
+	Hs
		1095093 ANKH1_HUMAN (709-1047): 1.35e-35: 150: 16.86		KLF10_HUMAN (246-400): 6.07e-28: 116: 44.52
+	Hs
		1118660 ANKH1_HUMAN (709-1047): 1.35e-35: 150: 16.86		KLF9_HUMAN (336-399): 6.96e-09: 58.2: 45.46