HitPredict

Interactor 1: NOD2 (Q9HC29)
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
Gene: NOD2

Interactor 2: NOD1 (Q9Y239)
Nucleotide-binding oligomerization domain-containing protein 1 (hNod1) (Caspase recruitment domain-containing protein 4)
Gene: NOD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 19898471
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, LRR_6~LRR_6, LRR_6~NACHT, NACHT~NACHT, NACHT~NLRC4_HD2, NACHT~NOD2_WH, NLRC4_HD2~NOD2_WH
Common GO terms GO:0002221 - pattern recognition receptor signaling pathway
GO:0002606 - positive regulation of dendritic cell antigen processing and presentation
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 25 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1040
Hs

1 953
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Service provided by Combinatics, Japan

Last updated: 11Aug2025