HitPredict

Interactor 1: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Interactor 2: SNX6 (Q9UNH7)
Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]
Gene: SNX6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1620 Hs			1 406
+	Hs
		1111993 ALK_HUMAN (1-1620): 0: 1901: 100.00		SNX1_HUMAN (32-404): 3.58e-86: 273: 20.96
+	Hs
		464080 RET_HUMAN (804-1477): 5.87e-139: 460: 23.15		SNX6_HUMAN (1-406): 6.86e-126: 371: 100.00
+	Hs
		439880 INSR_HUMAN (973-1436): 1e-112: 392: 34.25		SNX6_HUMAN (1-406): 6.86e-126: 371: 100.00
+	Hs
		465694 IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77		SNX6_HUMAN (1-406): 6.86e-126: 371: 100.00
+	Hs
		477273 ROS1_HUMAN (1039-1461): 3.97e-112: 397: 37.75		SNX5_HUMAN (13-405): 3.77e-112: 336: 64.38
+	Hs
		439892 INSR_HUMAN (973-1436): 1e-112: 392: 34.25		SNX5_HUMAN (13-405): 3.77e-112: 336: 64.38
+	Hs
		465702 IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77		SNX5_HUMAN (13-405): 3.77e-112: 336: 64.38
+	Hs
		255362 INSR_HUMAN (973-1436): 1e-112: 392: 34.25		SNX2_HUMAN (16-404): 1.6e-93: 292: 21.31
+	Rn
		74722 INSR_RAT (973-1484): 1.46e-112: 392: 32.38		B2RYP4_RAT (16-404): 3.4e-93: 291: 21.55
+	Hs
		255363 IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77		SNX2_HUMAN (16-404): 1.6e-93: 292: 21.31
+	Hs
		439727 INSR_HUMAN (973-1436): 1e-112: 392: 34.25		SNX1_HUMAN (32-404): 3.58e-86: 273: 20.96
+	Hs
		465514 IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77		SNX1_HUMAN (32-404): 3.58e-86: 273: 20.96
+	Mm
		581966 INSR_MOUSE (973-1484): 6.99e-113: 392: 32.38		SNX9_MOUSE (25-402): 6.42e-82: 264: 12.15
+	Mm
		1221440 IGF1R_MOUSE (1037-1468): 4.99e-110: 384: 33.48		SNX9_MOUSE (25-402): 6.42e-82: 264: 12.15
+	Hs
		1157113 NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03		SNX6_HUMAN (1-406): 6.86e-126: 371: 100.00
+	Hs
		329815 INSR_HUMAN (973-1436): 1e-112: 392: 34.25		SNX4_HUMAN (14-403): 5.03e-57: 195: 15.54
+	Hs
		255356 NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07		SNX2_HUMAN (16-404): 1.6e-93: 292: 21.31
+	Hs
		411891 NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07		SNX1_HUMAN (32-404): 3.58e-86: 273: 20.96
+	Hs
		412894 NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07		SNX9_HUMAN (25-402): 1.44e-80: 260: 12.41
+	Hs
		1157112 NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03		SNX7_HUMAN (24-399): 4.14e-75: 240: 16.75