HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SNX1 (Q13596)
Sorting nexin-1
Gene: SNX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9819414
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005764 - lysosome GO:0010008 - endosome membrane GO:0016020 - membrane GO:0031623 - receptor internalization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 522
+	Hs
		255362 INSR_HUMAN (1-1382): 0: 1513: 100.00		SNX2_HUMAN (10-522): 3.63e-127: 382: 58.95
+	Rn
		74722 INSR_RAT (1-1382): 0: 1513: 94.29		B2RYP4_RAT (10-522): 8.43e-125: 376: 58.95
+	Mm
		581966 INSR_MOUSE (1-1382): 0: 1494: 94.22		SNX9_MOUSE (4-518): 6.32e-96: 304: 13.88
+	Hs
		465514 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SNX1_HUMAN (1-522): 8.24e-149: 438: 100.00
+	Hs
		329815 INSR_HUMAN (1-1382): 0: 1513: 100.00		SNX4_HUMAN (95-516): 2.26e-75: 246: 14.75
+	Hs
		439892 INSR_HUMAN (1-1382): 0: 1513: 100.00		SNX5_HUMAN (142-520): 9.17e-75: 243: 21.45
+	Hs
		439880 INSR_HUMAN (1-1382): 0: 1513: 100.00		SNX6_HUMAN (145-520): 1.82e-73: 240: 20.46
+	Hs
		255363 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SNX2_HUMAN (10-522): 3.63e-127: 382: 58.95
+	Mm
		1221440 IGF1R_MOUSE (19-1380): 0: 1343: 55.37		SNX9_MOUSE (4-518): 6.32e-96: 304: 13.88
+	Rn
		72607 INSR_RAT (1-1382): 0: 1513: 94.29		B0BMY2_RAT (118-249): 1.84e-34: 128: 25.00
+	Hs
		465702 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SNX5_HUMAN (142-520): 9.17e-75: 243: 21.45
+	Hs
		465694 IGF1R_HUMAN (31-1380): 0: 1344: 56.62		SNX6_HUMAN (145-520): 1.82e-73: 240: 20.46
+	Hs
		710228 EPHA2_HUMAN (521-1320): 1.66e-176: 552: 20.02		SNX1_HUMAN (1-522): 8.24e-149: 438: 100.00
+	Hs
		255403 EPHA5_HUMAN (521-1319): 0: 575: 22.17		SNX2_HUMAN (10-522): 3.63e-127: 382: 58.95
+	Hs
		931916 EPHA5_HUMAN (521-1319): 0: 575: 22.17		SNX6_HUMAN (145-520): 1.82e-73: 240: 20.46
+	Hs
		1111993 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		SNX1_HUMAN (1-522): 8.24e-149: 438: 100.00
+	Hs
		411891 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		SNX1_HUMAN (1-522): 8.24e-149: 438: 100.00
+	Hs
		255356 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		SNX2_HUMAN (10-522): 3.63e-127: 382: 58.95
+	Hs
		412894 NTRK1_HUMAN (996-1286): 9.2e-68: 247: 42.62		SNX9_HUMAN (2-518): 1.34e-93: 298: 14.58
+	Hs
		1461996 ALK_HUMAN (982-1339): 1.97e-70: 263: 40.53		SNX6_HUMAN (145-520): 1.82e-73: 240: 20.46