HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21451109
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 317
+	Hs
		433258 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		522789 SRC_HUMAN (35-219): 4.06e-46: 161: 17.13		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		639811 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		548643 VAV_HUMAN (41-173): 4.43e-27: 110: 18.05		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		639676 P85A_HUMAN (35-153): 1.46e-17: 82.9: 18.49		IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00
+	Hs
		433701 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		ANK2_HUMAN (118-315): 9.61e-41: 153: 23.50
+	Mm
		140058 P85B_MOUSE (37-161): 8.4e-19: 86.4: 21.60		NFKB1_MOUSE (70-302): 5.46e-66: 224: 38.98
+	Dm
		337696 SRC64_DROME (34-223): 2.87e-42: 151: 16.00		TNKS_DROME (115-314): 1.05e-33: 133: 19.73
+	Hs
		433730 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Hs
		412002 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		BCL3_HUMAN (26-234): 3e-29: 118: 24.76
+	Hs
		411697 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		ANK3_HUMAN (1-130): 1.86e-30: 123: 10.77
+	Hs
		411590 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		BCL3_HUMAN (26-234): 3e-29: 118: 24.76
+	Hs
		147387 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35
+	Hs
		434071 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33
+	Hs
		411885 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		KDIS_HUMAN (225-314): 1.26e-20: 94.5: 13.33
+	Hs
		883587 P55G_HUMAN (18-147): 3.64e-21: 92.9: 16.15		RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31
+	Hs
		1267436 P55G_HUMAN (18-147): 3.64e-21: 92.9: 16.15		Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31
+	Hs
		434072 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		ANR50_HUMAN (2-66): 2.02e-09: 60.6: 4.62
+	Hs
		655290 P85A_HUMAN (35-153): 1.46e-17: 82.9: 18.49		RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31
+	Hs
		1267413 P55G_HUMAN (18-147): 3.64e-21: 92.9: 16.15		ANS1A_HUMAN (173-293): 8.47e-20: 92: 20.16