HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: LEPR (P48357)
Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.50	0.543

Property	Details
Experiments	11018044, 21239736
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1165
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (1-1165): 0: 858: 75.30
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (1-1165): 0: 858: 75.30
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (1-1165): 0: 858: 75.30
+	Mm
		817306 CISH_MOUSE (13-221): 1.36e-46: 156: 29.86		LEPR_MOUSE (1-1165): 0: 858: 75.30
+	Hs
		362705 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FINC_HUMAN (306-1127): 3.98e-50: 197: 11.07
+	Hs
		362685 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		FINC_HUMAN (306-1127): 3.98e-50: 197: 11.07
+	Hs
		433804 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		SDK2_HUMAN (15-896): 3.29e-51: 200: 12.95
+	Mm
		56907 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		PTPRF_MOUSE (536-1137): 9.03e-27: 121: 9.33
+	Hs
		411959 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRF_HUMAN (536-1137): 1.29e-26: 120: 9.62
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (201-885): 9.48e-22: 104: 14.13
+	Hs
		411565 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		PTPRF_HUMAN (536-1137): 1.29e-26: 120: 9.62
+	Hs
		147398 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL6RB_HUMAN (208-885): 2.98e-18: 92.6: 13.86
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (208-885): 2.98e-18: 92.6: 13.86
+	Hs
		147385 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PRLR_HUMAN (427-646): 1.43e-14: 80.2: 21.93
+	Hs
		412016 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRD_HUMAN (25-939): 1.98e-16: 87.4: 10.14
+	Hs
		147442 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CSF3R_HUMAN (195-755): 9.76e-12: 71.5: 12.63
+	Hs
		147443 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I12R2_HUMAN (482-918): 1.23e-10: 68: 13.20
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (195-755): 9.76e-12: 71.5: 12.63
+	Hs
		433961 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		CSF3R_HUMAN (195-755): 9.76e-12: 71.5: 12.63
+	Mm
		435879 HCK_MOUSE (14-223): 4.94e-46: 161: 15.04		CSF3R_MOUSE (200-739): 1.88e-11: 70.7: 11.70