HitPredict

Interactor 1: CDC20 (Q12834)
Cell division cycle protein 20 homolog (p55CDC)
Gene: CDC20

Interactor 2: MD2L2 (Q9UI95)
Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7)
Gene: MAD2L2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	11459826, 30154076, 17719540
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HORMA~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005819 - spindle GO:0007094 - mitotic spindle assembly checkpoint signaling GO:0051301 - cell division
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 211
+	Hs
		1017373 CDC20_HUMAN (1-499): 1.18e-136: 405: 100.00		MD2L1_HUMAN (4-203): 9.75e-61: 190: 23.04
+	Dm
		1095724 Q24044_DROME (1-483): 1.33e-96: 303: 48.34		Q9VRQ2_DROME (2-203): 4.19e-60: 188: 20.48
+	Hs
		1288367 SNR40_HUMAN (340-499): 1.5e-30: 123: 20.25		MD2L2_HUMAN (1-211): 2.72e-87: 258: 100.00
+	Hs
		1355731 FZR1_HUMAN (315-495): 1.51e-24: 108: 19.02		MD2L2_HUMAN (1-211): 2.72e-87: 258: 100.00
+	Ce
		998496 FZY1_CAEEL (143-478): 3.64e-38: 147: 28.76		Q9NGT3_CAEEL (1-207): 1.15e-61: 192: 18.87
+	At
		1339754 CDC21_ARATH (378-499): 4.89e-16: 82.3: 17.32		MAD2_ARATH (3-203): 3.89e-71: 216: 22.93
+	At
		1339749 CDC22_ARATH (378-499): 5.64e-16: 81.9: 17.32		MAD2_ARATH (3-203): 3.89e-71: 216: 22.93
+	Sc
		640848 CDC20_YEAST (315-495): 5.18e-14: 76.6: 18.13		MAD2_YEAST (10-199): 9.82e-57: 179: 26.02
+	Hs
		1029237 TAF5_HUMAN (239-336): 9.1e-10: 63.2: 37.00		MD2L1_HUMAN (4-203): 9.75e-61: 190: 23.04