HitPredict

Interactor 1: STXB1 (P61764)
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
Gene: STXBP1

Interactor 2: STX19 (Q8N4C7)
Syntaxin-19
Gene: STX19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	25416956, 25910212, 32296183, 26186194, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid bait and prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Sec1~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 594 Hs			1 294
+	Mm
		147920 STXB1_MOUSE (1-594): 0: 680: 100.00		STX1A_MOUSE (8-288): 1.56e-68: 216: 28.72
+	Bt
		746102 STXB1_BOVIN (1-594): 0: 680: 100.00		STX1A_BOVIN (8-288): 8.71e-69: 216: 28.72
+	Rn
		746108 STXB1_RAT (1-594): 0: 680: 100.00		STX1A_RAT (8-288): 2.28e-68: 215: 29.08
+	Hs
		963424 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1A_HUMAN (8-288): 8.65e-68: 214: 28.72
+	Mm
		147935 STXB1_MOUSE (1-594): 0: 680: 100.00		STX1B_MOUSE (8-288): 3.73e-67: 212: 28.01
+	Rn
		960333 STXB1_RAT (1-594): 0: 680: 100.00		STX1B_RAT (8-288): 3.73e-67: 212: 28.01
+	Hs
		960338 STXB1_HUMAN (1-594): 0: 680: 100.00		STX1B_HUMAN (8-288): 3.73e-67: 212: 28.01
+	Hs
		746189 STXB1_HUMAN (1-594): 0: 680: 100.00		STX2_HUMAN (24-288): 5.13e-65: 207: 26.32
+	Rn
		894400 STXB1_RAT (1-594): 0: 680: 100.00		STX2_RAT (29-283): 9.03e-62: 199: 27.34
+	Mm
		204928 STXB2_MOUSE (1-593): 0: 659: 62.80		STX1A_MOUSE (8-288): 1.56e-68: 216: 28.72
+	Hs
		286641 STXB1_HUMAN (1-594): 0: 680: 100.00		STX11_HUMAN (1-290): 1.65e-58: 190: 36.43
+	Hs
		963409 STXB1_HUMAN (1-594): 0: 680: 100.00		STX4_HUMAN (8-289): 1.34e-56: 186: 27.47
+	Hs
		746199 STXB2_HUMAN (1-593): 0: 658: 63.47		STX2_HUMAN (24-288): 5.13e-65: 207: 26.32
+	Mm
		147939 STXB1_MOUSE (1-594): 0: 680: 100.00		STX4_MOUSE (8-289): 8.48e-54: 178: 25.00
+	Rn
		963484 STXB1_RAT (1-594): 0: 680: 100.00		STX4_RAT (8-289): 4.78e-53: 176: 25.00
+	Hs
		963413 STXB1_HUMAN (1-594): 0: 680: 100.00		STX3_HUMAN (1-281): 1.77e-52: 175: 29.08
+	Rn
		963483 STXB1_RAT (1-594): 0: 680: 100.00		STX3_RAT (1-281): 1.8e-51: 172: 28.72
+	Hs
		286656 STXB2_HUMAN (1-593): 0: 658: 63.47		STX11_HUMAN (1-290): 1.65e-58: 190: 36.43
+	Mm
		1000451 STXB2_MOUSE (1-593): 0: 659: 62.80		STX4_MOUSE (8-289): 8.48e-54: 178: 25.00
+	Mm
		1225641 STXB2_MOUSE (1-593): 0: 659: 62.80		STX3_MOUSE (1-281): 3.25e-51: 171: 28.72