HitPredict

Interactor 1: STX11 (O75558)
Syntaxin-11
Gene: STX11

Interactor 2: STXB1 (P61764)
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
Gene: STXBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.939

Property	Details
Experiments	25416956, 25910212, 28514442, 33961781, unassigned3799
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Sec1~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 287 Hs			1 594
+	Bt
		746102 STX1A_BOVIN (1-286): 1.04e-71: 224: 28.67		STXB1_BOVIN (1-594): 0: 680: 100.00
+	Mm
		147920 STX1A_MOUSE (1-286): 2.39e-71: 223: 28.67		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Mm
		147935 STX1B_MOUSE (1-286): 1.33e-71: 223: 32.17		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Rn
		746108 STX1A_RAT (1-286): 3.03e-71: 223: 28.67		STXB1_RAT (1-594): 0: 680: 100.00
+	Rn
		960333 STX1B_RAT (1-286): 1.33e-71: 223: 32.17		STXB1_RAT (1-594): 0: 680: 100.00
+	Hs
		960338 STX1B_HUMAN (1-286): 1.33e-71: 223: 32.17		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Hs
		963424 STX1A_HUMAN (1-286): 2.83e-70: 220: 28.67		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Hs
		746189 STX2_HUMAN (1-286): 7.66e-68: 214: 31.82		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Rn
		894400 STX2_RAT (1-278): 5.81e-65: 206: 32.37		STXB1_RAT (1-594): 0: 680: 100.00
+	Mm
		204928 STX1A_MOUSE (1-286): 2.39e-71: 223: 28.67		STXB2_MOUSE (1-593): 0: 659: 62.80
+	Hs
		746199 STX2_HUMAN (1-286): 7.66e-68: 214: 31.82		STXB2_HUMAN (1-593): 0: 658: 63.47
+	Rn
		746113 STX1A_RAT (1-286): 3.03e-71: 223: 28.67		STXB2_RAT (1-593): 0: 647: 62.35
+	Hs
		963409 STX4_HUMAN (1-286): 1.55e-58: 190: 27.53		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Hs
		286656 STX11_HUMAN (1-287): 1.26e-63: 203: 100.00		STXB2_HUMAN (1-593): 0: 658: 63.47
+	Rn
		894401 STX2_RAT (1-278): 5.81e-65: 206: 32.37		STXB2_RAT (1-593): 0: 647: 62.35
+	Dm
		1059140 STX1A_DROME (10-286): 7.21e-68: 214: 26.72		ROP_DROME (4-589): 0: 623: 62.67
+	Ce
		194913 STX1A_CAEEL (2-286): 5.02e-66: 209: 28.42		UNC18_CAEEL (4-590): 0: 603: 58.11
+	Hs
		125717 STX2_HUMAN (1-286): 7.66e-68: 214: 31.82		STXB3_HUMAN (1-593): 0: 584: 50.59
+	Hs
		125737 STX4_HUMAN (1-286): 1.55e-58: 190: 27.53		STXB3_HUMAN (1-593): 0: 584: 50.59
+	Dm
		1172792 STX1A_DROME (10-286): 7.21e-68: 214: 26.72		SLY1_DROME (5-586): 5.18e-142: 427: 13.77