HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	30236924, 22787435
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1130
+	Hs
		362129 HCK_HUMAN (14-223): 1e-48: 168: 16.26		ABL1_HUMAN (1-1130): 0: 987: 100.00
+	Hs
		473378 HCK_HUMAN (14-223): 1e-48: 168: 16.26		ABL2_HUMAN (10-1130): 0: 774: 52.53
+	Hs
		462963 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		440300 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		473361 HCK_HUMAN (14-223): 1e-48: 168: 16.26		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		155151 SOCS7_HUMAN (13-221): 6.01e-51: 175: 24.17		YES_HUMAN (5-510): 5.81e-179: 536: 39.42
+	Hs
		155896 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		YES_HUMAN (5-510): 5.81e-179: 536: 39.42
+	Hs
		462945 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		YES_HUMAN (5-510): 5.81e-179: 536: 39.42
+	Hs
		462953 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FGR_HUMAN (2-510): 8.58e-178: 533: 38.80
+	Hs
		155893 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		LCK_HUMAN (9-508): 2.02e-177: 531: 38.49
+	Hs
		439905 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		LCK_HUMAN (9-508): 2.02e-177: 531: 38.49
+	Mm
		440286 SOCS6_MOUSE (34-220): 9.79e-49: 168: 26.32		LCK_MOUSE (9-508): 3.26e-179: 536: 38.30
+	Hs
		439912 HCK_HUMAN (14-223): 1e-48: 168: 16.26		LCK_HUMAN (9-508): 2.02e-177: 531: 38.49
+	Mm
		571265 FGR_MOUSE (35-223): 1.11e-47: 165: 15.46		FGR_MOUSE (4-510): 1.33e-177: 532: 38.51
+	Hs
		473348 HCK_HUMAN (14-223): 1e-48: 168: 16.26		HCK_HUMAN (9-508): 2.76e-174: 524: 38.79
+	Hs
		462946 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		LYN_HUMAN (9-508): 2.82e-172: 518: 36.15
+	Hs
		463286 HCK_HUMAN (14-223): 1e-48: 168: 16.26		LYN_HUMAN (9-508): 2.82e-172: 518: 36.15
+	Hs
		155925 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		BLK_HUMAN (9-508): 9.47e-165: 498: 38.33
+	Hs
		473402 HCK_HUMAN (14-223): 1e-48: 168: 16.26		BTK_HUMAN (5-501): 7.21e-156: 481: 36.56
+	Hs
		155921 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		TXK_HUMAN (27-500): 5.05e-154: 471: 36.07