HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 543
+	Hs
		155151 SOCS7_HUMAN (13-221): 6.01e-51: 175: 24.17		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		462945 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		462963 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		SRC_HUMAN (1-543): 0: 602: 74.22
+	Hs
		473361 HCK_HUMAN (14-223): 1e-48: 168: 16.26		SRC_HUMAN (1-543): 0: 602: 74.22
+	Hs
		440300 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FYN_HUMAN (1-543): 0: 584: 72.16
+	Hs
		462953 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		FGR_HUMAN (1-542): 0: 564: 67.10
+	Hs
		155893 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		439905 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		473348 HCK_HUMAN (14-223): 1e-48: 168: 16.26		HCK_HUMAN (1-541): 0: 545: 57.49
+	Mm
		440286 SOCS6_MOUSE (34-220): 9.79e-49: 168: 26.32		LCK_MOUSE (83-541): 0: 544: 60.78
+	Hs
		439912 HCK_HUMAN (14-223): 1e-48: 168: 16.26		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		462946 YES_HUMAN (15-223): 1.67e-50: 173: 13.33		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		463286 HCK_HUMAN (14-223): 1e-48: 168: 16.26		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		155925 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		BLK_HUMAN (66-541): 1.31e-174: 504: 58.70
+	Hs
		473378 HCK_HUMAN (14-223): 1e-48: 168: 16.26		ABL2_HUMAN (9-543): 6.98e-166: 503: 37.96
+	Hs
		155888 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		ABL1_HUMAN (41-543): 1.77e-161: 490: 39.10
+	Hs
		362129 HCK_HUMAN (14-223): 1e-48: 168: 16.26		ABL1_HUMAN (41-543): 1.77e-161: 490: 39.10
+	Hs
		473402 HCK_HUMAN (14-223): 1e-48: 168: 16.26		BTK_HUMAN (4-537): 6.44e-167: 490: 31.35
+	Hs
		155921 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		TXK_HUMAN (87-532): 5.4e-166: 483: 37.09
+	Hs
		155941 SOCS3_HUMAN (1-225): 6.21e-54: 174: 100.00		PTK6_HUMAN (88-535): 2.05e-164: 476: 42.83