HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 328
+	Hs
		161502 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38
+	Hs
		161490 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		POC1A_HUMAN (168-327): 7.34e-25: 105: 11.74
+	Hs
		161443 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		WDR5_HUMAN (209-320): 1.01e-18: 87: 16.96
+	Hs
		161486 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		WDR5B_HUMAN (208-320): 1.09e-18: 87: 16.81
+	Hs
		224298 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00
+	Hs
		1380086 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38
+	Hs
		1155633 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38
+	Hs
		965167 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		WDR5_HUMAN (209-320): 1.01e-18: 87: 16.96
+	Dm
		1208005 SET1_DROME (5244-5537): 1.14e-75: 284: 28.49		WDS_DROME (1-166): 9.1e-38: 139: 14.61
+	Hs
		224269 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00
+	Hs
		224397 KMT2B_HUMAN (79-219): 7.15e-25: 118: 24.31		BUB3_HUMAN (1-328): 2.34e-94: 284: 100.00
+	Hs
		216486 SUV91_HUMAN (5165-5536): 1.72e-93: 313: 18.38		DAW1_HUMAN (194-326): 1.15e-15: 78.9: 14.18
+	Hs
		284952 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		TAF5L_HUMAN (17-146): 4.72e-09: 59.3: 36.23
+	At
		1421791 ATX1_ARATH (5318-5537): 4.12e-68: 255: 33.20		WDR5A_ARATH (218-316): 7.18e-16: 78.9: 12.50
+	Hs
		1041577 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		FBXW7_HUMAN (1-202): 4.67e-46: 167: 20.38
+	Hs
		1041578 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		SNR40_HUMAN (1-122): 1.14e-23: 101: 16.54
+	Hs
		964869 KMT2A_HUMAN (218-352): 4.01e-30: 135: 26.24		WDR5_HUMAN (209-320): 1.01e-18: 87: 16.96
+	Hs
		1387641 KMT2B_HUMAN (79-219): 7.15e-25: 118: 24.31		SNR40_HUMAN (1-122): 1.14e-23: 101: 16.54
+	Hs
		1387546 NSD3_HUMAN (175-342): 4.38e-22: 108: 18.29		SNR40_HUMAN (1-122): 1.14e-23: 101: 16.54
+	Hs
		965330 KMT2B_HUMAN (79-219): 7.15e-25: 118: 24.31		WDR5_HUMAN (209-320): 1.01e-18: 87: 16.96