Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5
Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 0.60 | 0.770 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23870121, 24680668, 27563068, 15199122, 28182322, 27192115, 31685992, 24981860, 27598236, 37722486, 18840606, 20581860, 22665483, 26186194, 28514442, 27705803, 31400120, 31544921, 32076268, 33022573 and 11 others
more... |
| Identification Methods | affinity chromatography technology, pull down, biochemical, unspecified method, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, surface plasmon resonance, tandem affinity purification, molecular sieving and 1 others
more... |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0042800 - histone H3K4 methyltransferase activity GO:0045815 - transcription initiation-coupled chromatin remodeling and 2 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
