HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: CYTSA (Q69YQ0)
Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)
Gene: SPECC1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28330616
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0015629 - actin cytoskeleton
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1030 Hs			1 1117
+	Hs
		161256 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		ACTN4_HUMAN (1009-1116): 6.66e-48: 187: 41.28
+	Hs
		161319 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77
+	Ce
		105086 G5ECD7_CAEEL (16-1029): 1.72e-71: 260: 21.10		H2L2C8_CAEEL (1009-1116): 1.45e-49: 192: 43.12
+	Ce
		105096 G5ECD7_CAEEL (16-1029): 1.72e-71: 260: 21.10		Q23158_CAEEL (1009-1116): 1.02e-46: 184: 40.37
+	Hs
		521508 DAPK1_HUMAN (43-515): 3.48e-54: 208: 15.55		ACTN1_HUMAN (1009-1116): 3.96e-50: 194: 42.20
+	Hs
		1148963 PP12C_HUMAN (538-1030): 4.93e-33: 139: 20.35		CYTSA_HUMAN (1-1117): 1.12e-71: 262: 100.00
+	Hs
		211541 DAPK1_HUMAN (43-515): 3.48e-54: 208: 15.55		ACTN4_HUMAN (1009-1116): 6.66e-48: 187: 41.28
+	Hs
		506803 ANK1_HUMAN (1-934): 3.93e-69: 255: 12.47		SPTB1_HUMAN (1012-1115): 7.3e-16: 85.5: 47.62
+	Hs
		865136 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		SMTN_HUMAN (1012-1115): 2.54e-15: 83.2: 41.51
+	Hs
		865152 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		SMTN_HUMAN (1012-1115): 2.54e-15: 83.2: 41.51
+	Ce
		107985 G5EG29_CAEEL (1-897): 2.49e-20: 99.2: 11.44		Q9XVU8_CAEEL (1009-1116): 2.61e-49: 191: 43.12
+	Mm
		57429 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		MYH9_MOUSE (1-938): 2.15e-39: 162: 8.52
+	Hs
		225128 MYPT2_HUMAN (1-905): 6.08e-21: 101: 11.37		MYH9_HUMAN (206-1087): 3.64e-34: 144: 11.77
+	Dm
		1303397 Q9VJ14_DROME (140-612): 6.22e-24: 111: 14.07		MYSN_DROME (348-1092): 6.68e-23: 108: 12.32
+	Mm
		57397 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		Q3UFT0_MOUSE (381-1087): 3.93e-26: 118: 11.14
+	Mm
		103598 ANK3_MOUSE (165-457): 5.34e-24: 111: 12.50		Q3UGX2_MOUSE (1012-1115): 6.16e-16: 85.5: 47.62