HitPredict

Interactor 1: RGS13 (O14921)
Regulator of G-protein signaling 13 (RGS13)
Gene: RGS13

Interactor 2: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12193720
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 159 Hs			1 355
+	Hs
		418623 RGS3_HUMAN (12-159): 1.87e-62: 209: 40.54		GNAI2_HUMAN (1-355): 8.82e-180: 503: 100.00
+	Hs
		303098 RGS20_HUMAN (18-157): 5.31e-62: 197: 42.86		GNAI2_HUMAN (1-355): 8.82e-180: 503: 100.00
+	Hs
		475923 RGS3_HUMAN (12-159): 1.87e-62: 209: 40.54		GNAI3_HUMAN (1-355): 8.25e-175: 491: 85.92
+	Hs
		303125 RGS20_HUMAN (18-157): 5.31e-62: 197: 42.86		GNAI1_HUMAN (1-355): 7.82e-178: 499: 87.89
+	Hs
		418622 RGS19_HUMAN (9-158): 3.76e-59: 184: 40.00		GNAI2_HUMAN (1-355): 8.82e-180: 503: 100.00
+	Hs
		989889 RGS17_HUMAN (2-158): 2.02e-60: 187: 35.67		GNAI1_HUMAN (1-355): 7.82e-178: 499: 87.89
+	Hs
		303102 RGS20_HUMAN (18-157): 5.31e-62: 197: 42.86		GNAO_HUMAN (1-355): 1.32e-173: 488: 69.30
+	Hs
		890627 RGS19_HUMAN (9-158): 3.76e-59: 184: 40.00		GNAI1_HUMAN (1-355): 7.82e-178: 499: 87.89
+	Hs
		297293 RGS9_HUMAN (5-155): 1.73e-58: 194: 30.72		GNAO_HUMAN (1-355): 1.32e-173: 488: 69.30
+	Hs
		475924 RGS7_HUMAN (5-156): 1.78e-57: 188: 28.95		GNAI3_HUMAN (1-355): 8.25e-175: 491: 85.92
+	Hs
		476055 RGS17_HUMAN (2-158): 2.02e-60: 187: 35.67		GNAI3_HUMAN (1-355): 8.25e-175: 491: 85.92
+	Hs
		475922 RGS19_HUMAN (9-158): 3.76e-59: 184: 40.00		GNAI3_HUMAN (1-355): 8.25e-175: 491: 85.92
+	Hs
		482588 RGS19_HUMAN (9-158): 3.76e-59: 184: 40.00		GNAO_HUMAN (1-355): 1.32e-173: 488: 69.30
+	Hs
		715999 RGS3_HUMAN (12-159): 1.87e-62: 209: 40.54		GNA11_HUMAN (1-354): 4.9e-162: 459: 50.42
+	Hs
		168014 RGS13_HUMAN (1-159): 2.76e-65: 198: 100.00		GNA11_HUMAN (1-354): 4.9e-162: 459: 50.42
+	Bt
		235272 RGS9_BOVIN (5-155): 5.39e-58: 189: 30.07		GNAT1_BOVIN (1-355): 1.09e-164: 465: 65.92
+	Hs
		890709 RGS7_HUMAN (5-156): 1.78e-57: 188: 28.95		GNAQ_HUMAN (1-354): 9.29e-165: 465: 50.42
+	Hs
		303104 RGS20_HUMAN (18-157): 5.31e-62: 197: 42.86		GNAZ_HUMAN (1-354): 7.1e-160: 453: 66.38
+	Hs
		618442 RGS7_HUMAN (5-156): 1.78e-57: 188: 28.95		GNAZ_HUMAN (1-354): 7.1e-160: 453: 66.38
+	Hs
		618441 RGS19_HUMAN (9-158): 3.76e-59: 184: 40.00		GNAZ_HUMAN (1-354): 7.1e-160: 453: 66.38