HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: KI2L4 (Q99706)
Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d)
Gene: KIR2DL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0031901 - early endosome membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 377
+	Hs
		65928 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		LIRA5_HUMAN (2-277): 1.77e-69: 222: 32.63
+	Hs
		169434 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR2_HUMAN (39-370): 1.45e-54: 194: 12.39
+	Hs
		169413 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR1_HUMAN (34-370): 4.36e-53: 190: 13.39
+	Hs
		169439 HGS_HUMAN (1-777): 1.57e-105: 343: 100.00		FGFR3_HUMAN (34-370): 1.56e-52: 188: 12.84
+	Hs
		65949 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		LIRA5_HUMAN (2-277): 1.77e-69: 222: 32.63
+	Hs
		641272 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		FGFR2_HUMAN (39-370): 1.45e-54: 194: 12.39
+	Hs
		541721 GGA3_HUMAN (6-678): 5.27e-48: 183: 13.96		FGFR1_HUMAN (34-370): 4.36e-53: 190: 13.39
+	Hs
		641227 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR2_HUMAN (39-370): 1.45e-54: 194: 12.39
+	Hs
		541620 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR1_HUMAN (34-370): 4.36e-53: 190: 13.39
+	Hs
		650332 STAM1_HUMAN (4-172): 1.4e-42: 164: 28.40		FGFR3_HUMAN (34-370): 1.56e-52: 188: 12.84
+	Hs
		336068 ZFYV9_HUMAN (155-539): 2.26e-38: 156: 19.00		FGFR2_HUMAN (39-370): 1.45e-54: 194: 12.39
+	Hs
		641203 ZFY16_HUMAN (137-496): 3.67e-38: 155: 17.80		FGFR2_HUMAN (39-370): 1.45e-54: 194: 12.39
+	Hs
		296435 STAM2_HUMAN (4-521): 1.15e-38: 153: 14.62		FGFR2_HUMAN (39-370): 1.45e-54: 194: 12.39
+	Hs
		336056 ZFYV9_HUMAN (155-539): 2.26e-38: 156: 19.00		FGFR1_HUMAN (34-370): 4.36e-53: 190: 13.39
+	Hs
		541566 ZFY16_HUMAN (137-496): 3.67e-38: 155: 17.80		FGFR1_HUMAN (34-370): 4.36e-53: 190: 13.39
+	Hs
		296429 STAM2_HUMAN (4-521): 1.15e-38: 153: 14.62		FGFR1_HUMAN (34-370): 4.36e-53: 190: 13.39
+	Hs
		296438 STAM2_HUMAN (4-521): 1.15e-38: 153: 14.62		FGFR3_HUMAN (34-370): 1.56e-52: 188: 12.84
+	Hs
		541734 ANFY1_HUMAN (156-219): 2.39e-14: 79.3: 50.00		FGFR1_HUMAN (34-370): 4.36e-53: 190: 13.39