HitPredict

Interactor 1: SHIP2 (O15357)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)
Gene: INPPL1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	9660833, 19380743, 10194451, 11349134
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1258 Hs			1 583
+	Mm
		957241 SHIP2_MOUSE (1-1258): 0: 956: 95.79		SHC1_MOUSE (1-583): 0: 527: 94.51
+	Mm
		957245 SHIP1_MOUSE (19-1216): 0: 706: 39.46		SHC1_MOUSE (1-583): 0: 527: 94.51
+	Hs
		666147 SHIP1_HUMAN (21-1197): 0: 699: 40.63		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Rn
		956852 SHIP1_RAT (19-1193): 0: 723: 40.17		SHC1_RAT (111-583): 1.45e-142: 422: 94.72
+	Hs
		176388 SHIP2_HUMAN (1-1258): 0: 968: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		129144 SHIP2_HUMAN (1-1258): 0: 968: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		176424 SHIP2_HUMAN (1-1258): 0: 968: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		442867 SHIP1_HUMAN (21-1197): 0: 699: 40.63		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Mm
		643112 SHIP1_MOUSE (19-1216): 0: 706: 39.46		P85A_MOUSE (300-581): 6.66e-38: 151: 15.99
+	Hs
		557759 SHIP1_HUMAN (21-1197): 0: 699: 40.63		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		655433 SHIP1_HUMAN (21-1197): 0: 699: 40.63		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Mm
		1141165 SHIP1_MOUSE (19-1216): 0: 706: 39.46		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48
+	Hs
		924742 SHIP1_HUMAN (21-1197): 0: 699: 40.63		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		203208 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		203218 SYNJ1_HUMAN (186-1224): 0: 604: 16.35		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Ce
		105280 SYNJ_CAEEL (172-984): 3.68e-168: 531: 17.66		Q95PW9_CAEEL (392-581): 3.88e-36: 141: 20.41
+	Hs
		924485 OCRL_HUMAN (230-895): 1.35e-168: 526: 19.28		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		166030 SYNJ2_HUMAN (708-1199): 8.8e-10: 65.8: 9.09		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		166032 SYNJ2_HUMAN (708-1199): 8.8e-10: 65.8: 9.09		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		166042 SYNJ2_HUMAN (708-1199): 8.8e-10: 65.8: 9.09		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48