HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: TCPH (Q99832)
T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]
Gene: CCT7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	28514442, 33961781, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 543
+	Hs
		1038670 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPH_HUMAN (1-543): 0: 647: 100.00
+	Hs
		177233 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		826651 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		177231 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		826803 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		821200 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		177188 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		821342 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		573251 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Sc
		693035 RPD3_YEAST (3-414): 0: 543: 57.07		TCPH_YEAST (2-542): 0: 587: 62.45
+	Sp
		140638 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPH_SCHPO (3-542): 0: 609: 64.97
+	Hs
		573401 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Sc
		693029 RPD3_YEAST (3-414): 0: 543: 57.07		TCPE_YEAST (2-526): 0: 568: 29.98
+	Sc
		693017 RPD3_YEAST (3-414): 0: 543: 57.07		TCPG_YEAST (2-527): 0: 546: 30.68
+	Sp
		140519 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPG_SCHPO (2-525): 0: 560: 31.77
+	Sp
		140725 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPE_SCHPO (3-528): 0: 544: 30.28
+	Sc
		760777 HOS2_YEAST (4-420): 1.09e-174: 497: 50.36		TCPG_YEAST (2-527): 0: 546: 30.68
+	Hs
		177239 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79
+	Hs
		843190 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79
+	Sp
		140614 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPD_SCHPO (20-518): 7.23e-89: 285: 34.50