HitPredict

Interactor 1: FYB1 (O15117)
FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)
Gene: FYB1

Interactor 2: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	15096483
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 783 Hs			1 128
+	Hs
		178067 FYB1_HUMAN (1-783): 1.62e-94: 314: 100.00		ABL1_HUMAN (1-127): 1.01e-39: 142: 26.72
+	Hs
		178069 FYB1_HUMAN (1-783): 1.62e-94: 314: 100.00		FYN_HUMAN (1-125): 4.26e-37: 133: 19.26
+	Hs
		178084 FYB1_HUMAN (1-783): 1.62e-94: 314: 100.00		GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69
+	Mm
		205165 FYB1_MOUSE (1-783): 6.32e-69: 245: 70.52		LCK_MOUSE (1-125): 1.43e-40: 142: 19.08
+	Mm
		205166 FYB1_MOUSE (1-783): 6.32e-69: 245: 70.52		LYN_MOUSE (1-125): 1.57e-39: 139: 19.85
+	Mm
		205167 FYB1_MOUSE (1-783): 6.32e-69: 245: 70.52		FYN_MOUSE (1-125): 4.05e-37: 133: 19.26
+	Hs
		440177 ASPP1_HUMAN (7-477): 8.15e-28: 122: 16.70		LCK_HUMAN (1-125): 8.6e-41: 143: 19.08
+	Hs
		463708 ASPP1_HUMAN (7-477): 8.15e-28: 122: 16.70		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Hs
		463610 MICA3_HUMAN (20-697): 6.83e-26: 116: 10.87		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Hs
		215893 SYNJ1_HUMAN (91-563): 7.15e-22: 103: 11.89		LCK_HUMAN (1-125): 8.6e-41: 143: 19.08
+	Hs
		440773 MAGL2_HUMAN (87-714): 1.74e-20: 99.3: 8.28		FYN_HUMAN (1-125): 4.26e-37: 133: 19.26
+	Hs
		319045 K0754_HUMAN (196-679): 7.6e-18: 91.2: 9.61		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Hs
		215914 SYNJ1_HUMAN (91-563): 7.15e-22: 103: 11.89		GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69
+	Hs
		551610 NFH_HUMAN (25-551): 3.15e-16: 85.3: 11.68		GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69
+	Hs
		440738 MAGE1_HUMAN (5-377): 7.76e-12: 71.1: 8.31		FYN_HUMAN (1-125): 4.26e-37: 133: 19.26
+	Hs
		463714 PRAM_HUMAN (8-540): 6.01e-10: 65: 12.15		LYN_HUMAN (1-125): 1.58e-39: 139: 19.85
+	Hs
		987833 PRG4_HUMAN (248-719): 2.82e-14: 79.2: 9.38		GRB2_HUMAN (1-123): 4.48e-35: 121: 19.69