HitPredict

Interactor 1: CFLAR (O15519)
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
Gene: CFLAR

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	18559494, 21474069
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002020 - protease binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process GO:0043525 - positive regulation of neuron apoptotic process and 1 others more... GO:0071456 - cellular response to hypoxia
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 393
+	Hs
		386744 CASP8_HUMAN (6-478): 8.27e-152: 442: 24.85		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386390 CASP7_HUMAN (183-478): 3.6e-92: 283: 21.38		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386254 CASP3_HUMAN (209-479): 8.43e-89: 274: 22.53		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386391 CASP6_HUMAN (228-479): 7.99e-83: 259: 22.42		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386181 CASPE_HUMAN (235-477): 4.29e-62: 204: 20.40		P53_HUMAN (1-393): 0: 619: 100.00