HitPredict

Interactor 1: EPHB6 (O15197)
Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)
Gene: EPHB6

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	9707552
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, PDZ~SAM_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1021 Hs			1 1824
+	Hs
		710800 EPHB2_HUMAN (33-1020): 0: 1118: 45.97		AFAD_HUMAN (1-1824): 0: 1266: 100.00
+	Hs
		931806 EPHB3_HUMAN (28-1021): 0: 1104: 44.44		AFAD_HUMAN (1-1824): 0: 1266: 100.00
+	Hs
		936333 EPHA7_HUMAN (16-1013): 0: 1104: 39.67		AFAD_HUMAN (1-1824): 0: 1266: 100.00
+	Hs
		710145 EPHA2_HUMAN (31-1017): 0: 988: 37.25		AFAD_HUMAN (1-1824): 0: 1266: 100.00
+	Hs
		710896 EPHB2_HUMAN (33-1020): 0: 1118: 45.97		GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06
+	Hs
		932138 EPHA4_HUMAN (14-1021): 0: 1111: 39.47		GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06
+	Hs
		1147439 EPHA7_HUMAN (16-1013): 0: 1104: 39.67		GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06
+	Hs
		710664 EPHA3_HUMAN (30-1021): 0: 1098: 38.87		GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06
+	Hs
		931902 EPHA5_HUMAN (18-1021): 0: 1093: 38.07		GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06
+	Hs
		181828 EPHB6_HUMAN (1-1021): 0: 1085: 100.00		GOPC_HUMAN (744-1091): 3.7e-40: 158: 15.06
+	Hs
		710831 EPHB2_HUMAN (33-1020): 0: 1118: 45.97		SCRIB_HUMAN (980-1700): 5.01e-22: 106: 16.02
+	Hs
		710820 EPHB2_HUMAN (33-1020): 0: 1118: 45.97		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83
+	Hs
		1122235 EPHA7_HUMAN (16-1013): 0: 1104: 39.67		SCRIB_HUMAN (980-1700): 5.01e-22: 106: 16.02
+	Hs
		932061 EPHA4_HUMAN (14-1021): 0: 1111: 39.47		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83
+	Hs
		1090129 EPHA7_HUMAN (16-1013): 0: 1104: 39.67		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83
+	Hs
		1147375 EPHA7_HUMAN (16-1013): 0: 1104: 39.67		LNX2_HUMAN (933-1089): 5.59e-18: 92.2: 19.75
+	Hs
		710622 EPHA3_HUMAN (30-1021): 0: 1098: 38.87		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83
+	Hs
		931840 EPHA5_HUMAN (18-1021): 0: 1093: 38.07		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83
+	Hs
		710238 EPHA2_HUMAN (31-1017): 0: 988: 37.25		SCRIB_HUMAN (980-1700): 5.01e-22: 106: 16.02
+	Hs
		710205 EPHA2_HUMAN (31-1017): 0: 988: 37.25		PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83