HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	29991678, 29674694, 34989544, 36934508, 10707961
Identification Methods	affinity chromatography technology, unspecified method, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0019221 - cytokine-mediated signaling pathway GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1154
+	Mm
		69806 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		B1ASP2_MOUSE (1-1154): 0: 1021: 94.63
+	Mm
		69808 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		B1ASP2_MOUSE (1-1154): 0: 1021: 94.63
+	Hs
		181748 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		JAK2_HUMAN (33-1153): 0: 799: 42.14
+	Mm
		193352 SOCS1_MOUSE (1-211): 7.14e-52: 167: 93.87		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Rn
		102468 G3V6B4_RAT (1-211): 9.05e-50: 162: 88.21		JAK2_RAT (33-1153): 0: 782: 41.54
+	Mm
		222647 SOCS5_MOUSE (3-210): 4.32e-45: 158: 18.98		JAK2_MOUSE (33-1153): 0: 778: 41.54
+	Hs
		181753 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ABL1_HUMAN (833-1154): 3.22e-95: 331: 29.72
+	Hs
		146668 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		YES_HUMAN (868-1151): 1.52e-97: 322: 30.53
+	Hs
		181783 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		SRC_HUMAN (868-1151): 7e-99: 326: 31.23
+	Hs
		181770 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		YES_HUMAN (868-1151): 1.52e-97: 322: 30.53
+	Hs
		181764 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44
+	Hs
		181765 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74
+	Hs
		181771 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23
+	Hs
		181824 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		BLK_HUMAN (853-1152): 7.51e-90: 300: 28.15
+	Dm
		337701 Q9VJA1_DROME (26-210): 3.45e-43: 154: 23.00		SRC64_DROME (843-1152): 5.53e-90: 302: 30.03
+	Hs
		181802 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		TYK2_HUMAN (867-1152): 1.57e-32: 139: 19.00
+	Hs
		181826 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		JAK3_HUMAN (855-1153): 6.11e-32: 137: 18.01
+	Hs
		181866 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		ERBB4_HUMAN (577-848): 1.87e-14: 80.5: 26.64
+	Hs
		256853 SOCS5_HUMAN (3-210): 3.81e-46: 161: 19.44		ERBB4_HUMAN (577-848): 1.87e-14: 80.5: 26.64
+	Hs
		181796 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		FGFR3_HUMAN (566-848): 5.13e-13: 75.5: 24.68