HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 368
+	Hs
		412329 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		SH3G3_HUMAN (1-368): 1.31e-87: 270: 66.30
+	Hs
		412328 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		SH3G2_HUMAN (1-368): 1.98e-84: 261: 68.75
+	Hs
		433485 YES_HUMAN (64-196): 8.58e-36: 133: 16.08		SHLB2_HUMAN (10-363): 1.2e-58: 196: 22.39
+	Hs
		561388 FER_HUMAN (4-176): 4.51e-37: 138: 15.56		SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16
+	Hs
		411763 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		RHG17_HUMAN (6-267): 6.29e-35: 137: 21.83
+	Hs
		411715 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82
+	Hs
		433350 YES_HUMAN (64-196): 8.58e-36: 133: 16.08		SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16
+	Rn
		71363 B2RZ33_RAT (17-175): 1.34e-36: 133: 21.25		SRC8_RAT (86-362): 8.29e-37: 140: 14.75
+	Hs
		146683 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		SH3R1_HUMAN (305-361): 9.5e-13: 71.7: 49.18
+	Hs
		146666 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		SRBS2_HUMAN (270-363): 9.46e-12: 68.6: 23.96
+	Hs
		146674 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		181839 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		209154 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		SRBS1_HUMAN (235-363): 3.59e-15: 79.2: 25.95
+	Hs
		924732 SOCS4_HUMAN (3-210): 8.16e-43: 151: 18.98		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924938 VAV3_HUMAN (5-209): 1.13e-39: 146: 15.24		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		855781 VAV2_HUMAN (1-175): 2.65e-39: 144: 17.68		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Mm
		1141129 VAV2_MOUSE (1-181): 1.07e-38: 143: 17.11		GRB2_MOUSE (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		208967 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		SRBS2_HUMAN (270-363): 9.46e-12: 68.6: 23.96
+	Mm
		763393 FYN_MOUSE (64-194): 1.54e-37: 138: 18.44		GRB2_MOUSE (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		557655 NCK1_HUMAN (17-175): 2.39e-36: 132: 21.25		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38